补肾解毒法治疗帕金森病轻度认知功能障碍的临床疗效观察

Clinical efficacy observation of treatment of mild cognitive impairment in Parkinson's disease by tonifying kidney and detoxicating method

目的:评价补肾解毒法治疗帕金森病轻度认知功能障碍的临床疗效和安全性,为探索中医药干预帕金森病轻度认知功能障碍的有效方法提供依据。方法:选取符合入组标准的102例帕金森病轻度认知功能障碍患者随机分为治疗组和对照组,治疗组服用中药"帕金森Ⅰ号",每日1剂,每次150mL,2次/d;对照组服用中药安慰剂每日1剂,每次150mL,2次/d。两组患者均口服多巴丝肼片,不服用其他改善认知的中西药。在治疗前、治疗4、8、12周后使用MMSE、MoCA量表、中医证候量表进行评价,治疗前及治疗后各1周内行血、尿便常规、肝肾功能、心电图等检查。结果:治疗组患者MMSE、MoCA评分及中医证候评分在治疗前后有显著性改善(P<0.05,P<0.01);治疗组与对照组患者在中医证候、认知功能方面有显著性差异(P<0.05,P<0.01),治疗组优于对照组。结论:补肾解毒法对于帕金森病轻度认知障碍患者的中医证候和认知功能有一定的改善作用。

Objective： To evaluate the clinical efficacy and safety of the tonifying kidney and detoxicating method in the treatment of mild cognitive impairment in Parkinson＇s disease, A total of and to explore the effective method of Chinese medicine intervention on Parkinson＇s disease mild cognitive impairment. Methods： A total of 102 patients with Parkinson＇s disease with mild cognitive impairment were randomly divided into two groups： treatment group and control group. The treatment group＇s patients were treated with ‘Parkinson Ⅰ＇1 dozen for 2 times per day, 150 mL each time, while the control group＇s patients were treated with traditional Chinese medicine placebo with the same oral method. The patients took the Madopar Tablets at the same time, and did not take other Chinese and western medicine that can improve cognition. MMSE, Mo CA scale and TCM syndrome scale were used to evaluate the curative effect at the prior treatment, 4 th week after treatment, 8 th week after treatment, and 12 th weeks after treatment. Routine blood test, routine urine and stool routine test, liver and kidney function and electrocardiogram were examined before and after treatment. Results： The MMSE, Mo CA score and TCM syndrome score of patients in the treatment group before and after treatment improved significantly（P〈0.05, P〈0.01）; the treatment group and the control group had significant difference in TCM syndrome and cognitive function（P〈0.05, P〈0.01）; the score of treatment group was better than that of the control group. Conclusion： The tonifying kidney and detoxicating method can improve the cognitive function of patients with Parkinson＇s disease.