中性粒细胞与淋巴细胞比值与2型糖尿病患者并发冠心病的相关性

The correlation between neutrophil to lymphocyte ratio and type 2 diabetes mellitus patients with coronary artery disease

目的:探讨中性粒细胞与淋巴细胞比值(NLR)与2型糖尿病(T2DM)患者并发冠心病的相关性。方法:收集T2DM患者330例,根据冠状动脉造影结果将研究对象分为冠心病组114例和对照组216例,采集各组外周静脉血进行中性粒细胞和淋巴细胞计数,计算NLR。Logistic回归分析T2DM并发冠心病的危险因素。结果:冠心病组与对照组间空腹血糖、高密度脂蛋白、肌酐、尿酸、NLR比值及吸烟率比较,差异有统计学意义(P<0.05);NLR>2.85组冠心病患者Gensini评分明显高于NLR≤1.99组和1.99<NLR≤2.85组冠心病患者的Gensini评分(P均<0.001);Logistic回归分析结果显示,NLR、LDL-C是T2DM患者并发冠心病的危险因素(OR值分别为3.282和1.603,P<0.05)。结论:NLR可能是T2DM患者并发冠心病的一个较好的相关性指标。

Objective： To investigate the relationship between neutrophil to lymphocyte ratio（ NLR）and type 2 diabetes mellitus（ T2DM） patients with coronary heart disease（ CAD）. Methods： 330 patients with T2DM were divided into CAD group（ n = 114） and control group（ n = 216） based on the result of coronary angiography. The peripheral venous blood was collected for neutrophils and lymphocyte count and NLR was calculated. Logistic regression was used to analyze the relationship between NLR and DM2 with CAD. Results： The fasting blood glucose,high density lipoprotein,creatinine,uric acid,NLR ratio and smoking rate were significantly higher than in CAD group when compared to the control group（ P〈0. 05）; Gensini score was gradually increased with the degree of NLR（ P〈0. 001）; Logistic regression analysis showed that NLR and LDL-C were risk factors for coronary heart disease in T2DM patients（ OR = 3. 282 and 1. 603,P all 0. 05）. Conclusion：NLR might be a good indicator for CAD in T2DM patients.