白细胞介素-26研究进展

Recent advances in interleukin-26

白细胞介素(interleukin,IL)-26最初被认为由T细胞特别是辅助性T细胞17产生。最近的研究发现,自然杀伤细胞、巨噬细胞、成纤维细胞和血管平滑肌细胞也产生IL-26。研究显示,IL-26能够特异性地结合到靶细胞的IL-10R2/IL-20R1受体复合物上,产生特定的胞内信号。除此以外,IL-26还可直接杀灭胞外细菌,并能与死亡细菌DNA或死亡细胞DNA片段结合形成IL-26-DNA复合物,激活浆细胞样树突状细胞Toll样受体9,分泌Ⅰ型干扰素IFN-α,在宿主防御和慢性炎性疾病中发挥重要作用。现对IL-26的结构、来源、受体和功能等进行综述。

Interleukin（IL）-26 was originally thought to be produced by T cells, especially the helper T cells 17. Recent studies have proved that natural killer cells, macrophages, fibroblasts and vascular smooth muscle cells can also produce IL-26. IL-26 has been proved to produce specific intracellular signatures, according to the IL-10 R2/IL-20 R1 receptor complexes. In addition, IL-26 can kill extracellular bacteria and form complexes with bacterial DNA and self-DNA released by dying bacteria and host cells. The IL-26-DNA complexes stimulate the secretion of type I interferon α by plasmacytoid dendritic cells via activation of Toll-like receptor 9. These findings provide insights into an important role of IL-26 in host defense and chronic inflammatory diseases. In the review, we summarized the structure, source, receptor and functions of IL-26.