肠源性氧化三甲胺在慢性肾病中的作用

Effect of intestinal TMAO on chronic kidney disease

氧化三甲胺是由人体正常消化产生并进入血液中的一种物质,一直以来被认为是正常的血液循环物质。但是近年来研究发现,氧化三甲胺具有生物活性,对多种慢性疾病都会产生不利影响。氧化三甲胺的产生主要依靠肠道菌群的代谢。在慢性肾脏疾病中,很多原因可导致肠道菌群发生改变,并且可以代谢生成氧化三甲胺的菌群种类明显升高,这就使慢性肾脏病患者血液中的氧化三甲胺含量上升。由于氧化三甲胺主要通过肾脏排泄,肾脏功能障碍可造成其在体内的积累,从而加剧慢性肾脏病患者的肾脏损伤。

TMAO is a normally digestion product which can enter human blood system. Considered as a normal blood circulation material, it has been found to have biological activity in recent years and has a negative effect on a variety of chronic diseases. The production of TMAO is mainly dependent on the metabolism of intestinal microbes. In chronic kidney disease, major changes in intestinal flora occur for a variety of reasons and can result in a significant increase in metabolites of TMAO-producing bacteria. This leads to an increase of blood TMAO in patients with chronic kidney disease and damage to the kidneys. Due to renal excretion of TMAO, and kidney dysfunction can lead to its accumulation, and further cause damage to kidney, which will exacerbate kidney damage in patients with chronic kidney disease.