摘要
目的:分析老年人收缩压变异性(BPV)与肾小球滤过率之间的关系。方法:在参加开滦研究队列第三次健康体检的人群中,采取整群抽样的方法随机抽取年龄≥60岁的开滦集团离退休员工进行24 h动态血压监测等检查。在随机抽取的3 064例受试者中,2 464例符合入选标准并接受肾功能测定,以估算肾小球滤过率(e GFR)作为肾功能评定指标,资料完整并符合入选标准者共1 382例。以短时收缩压极差(MMD)作为收缩压变异性指标,采用逐步线性回归方法,分析收缩压MMD与e GFR的相关性。结果:1 382例受试者的平均年龄为(67.16±5.86)岁,其中男性905例(65.5%);e GFR水平随着收缩压MMD的增加而降低(P<0.05);Pearson相关分析结果显示,e GFR与24 h、日间、夜间收缩压MMD均呈负相关(P<0.05)。多因素逐步线性回归分析结果显示,24 h、日间收缩压MMD与e GFR呈负线性相关。结论:24 h和日间收缩压MMD与e GFR呈负线性相关。
Objectives: To investigate the correlation between the systolic blood pressure variability and glomerular filtration rate in the elderly.Methods: From retired employees who participated in the third time physical examination of Kailuan group to underwent 24-hour ambulatory blood pressure monitoring. A total of 3 064 subjects aged over 60 years were recruited by cluster sampling method. 2 464 participants who met the inclusion were included and tested the renal function, with estimated glomerular filtration rate(e GFR) as indicators of renal function evaluation. Finally, 1 382 cases up to the standard. Multiviate regression models were performed to analyze the correlataion beteen short-term MMD and e GFR.Results: The mean age of 1 382 participants was(67.16±5.86) years, and 905 individuals(65.5%) were male. Levels of e GFR decreased with the increased of MMD(P〈0.05). Pearson correlation analysis indicated that e GFR was positively correlated with 24 hr-MMD、day-MMD and night-MMD(P〈0.05). Multivarite linear regrsssion analysis indicated that 24 hr-MMD、day-MMD were correlated with e GFR.Conclusions: 24 hr-MMD、day-MMD are correlated with e GFR.
作者
王玉珍
宋路
吴寿岭
王秀艳
WANG Yu-zhen;SONG Lu;WU Shou-ling;WANG Xiu-yan(Geriatric Department, Kailuan General Hospital, Tangshan(063000), Hebei, Chin)
出处
《中国循环杂志》
CSCD
北大核心
2018年第6期591-595,共5页
Chinese Circulation Journal
关键词
老年人
收缩压变异性
肾小球滤过率
Elderly
Systolic blood pressure variability
Glomerular filtration rate