老年人收缩压变异性与肾小球滤过率的关系

Relationship Between the Systolic Blood Pressure Variability and Glomerular Filtration Rate in the Elderly

目的:分析老年人收缩压变异性(BPV)与肾小球滤过率之间的关系。方法:在参加开滦研究队列第三次健康体检的人群中,采取整群抽样的方法随机抽取年龄≥60岁的开滦集团离退休员工进行24 h动态血压监测等检查。在随机抽取的3 064例受试者中,2 464例符合入选标准并接受肾功能测定,以估算肾小球滤过率(e GFR)作为肾功能评定指标,资料完整并符合入选标准者共1 382例。以短时收缩压极差(MMD)作为收缩压变异性指标,采用逐步线性回归方法,分析收缩压MMD与e GFR的相关性。结果:1 382例受试者的平均年龄为(67.16±5.86)岁,其中男性905例(65.5%);e GFR水平随着收缩压MMD的增加而降低(P<0.05);Pearson相关分析结果显示,e GFR与24 h、日间、夜间收缩压MMD均呈负相关(P<0.05)。多因素逐步线性回归分析结果显示,24 h、日间收缩压MMD与e GFR呈负线性相关。结论:24 h和日间收缩压MMD与e GFR呈负线性相关。

Objectives： To investigate the correlation between the systolic blood pressure variability and glomerular filtration rate in the elderly.Methods： From retired employees who participated in the third time physical examination of Kailuan group to underwent 24-hour ambulatory blood pressure monitoring. A total of 3 064 subjects aged over 60 years were recruited by cluster sampling method. 2 464 participants who met the inclusion were included and tested the renal function, with estimated glomerular filtration rate（e GFR） as indicators of renal function evaluation. Finally, 1 382 cases up to the standard. Multiviate regression models were performed to analyze the correlataion beteen short-term MMD and e GFR.Results： The mean age of 1 382 participants was（67.16±5.86） years, and 905 individuals（65.5%） were male. Levels of e GFR decreased with the increased of MMD（P〈0.05）. Pearson correlation analysis indicated that e GFR was positively correlated with 24 hr-MMD、day-MMD and night-MMD（P〈0.05）. Multivarite linear regrsssion analysis indicated that 24 hr-MMD、day-MMD were correlated with e GFR.Conclusions： 24 hr-MMD、day-MMD are correlated with e GFR.