嗜中性粒细胞胞外诱捕网对缺血再灌注损伤的影响及中医药干预研究进展

Effects of neutrophil extracellular traps on ischemia-reperfusion injury and intervention of traditional Chinese medicine

嗜中性粒细胞胞外诱捕网(neutrophil extracellular traps,NETs)是由活化的嗜中性粒细胞释放到胞外的网状结构物,它是嗜中性粒细胞死亡的一种形式,其与多种炎性反应和自身免疫性疾病相关。NETs既能捕杀病原微生物,也能加剧缺血再灌注组织或器官的损伤。研究显示,缺血再灌注损伤(ischemia and reperfusion injury,I/R)部位中存在大量NETs,而西药靶向阻断或减少NETs形成可以减轻由此造成的损伤;且中药中的某些成分也可以抑制NETs形成,这为中药的抗炎研究开拓了新的方向。

Neutrophil extracellular traps（ NETs） is a reticular structure released from activated neutrophils to the outside of cells. It is one of the forms of neutrophil death,which is associated with various inflammatory reaction and autoimmune diseases. NETs can not only kill pathogenic microorganisms,but also aggravate ischemia and reperfusion injury of tissues or organs. Researches have revealed that a large number of NETs can be found in the site of ischemia-reperfusion injury,and western medicine targeted blocking or reduction of NETs formation can alleviate the damage. It has also showed that certain ingredients of Chinese medicine can inhibit the NETs formation,which could broaden the new direction for anti-inflammation study of Chinese medicine.