电针治疗高脂血症动物实验的质量评价

Evaluation of Experimental Quality of Electro Acupuncture for Hyperlipidemic Animals

目的:系统评价电针治疗高脂血症动物实验的有效性和安全性。方法:以"针刺""电针""血脂异常"及"高脂血症"等为关键词,计算机检索2017年10月10日以前中国知网(CNKI)、万方、维普中文科技期刊数据库(VIP)、CBM、Pub Med、EMBASE和Cochrane图书馆等数据库,采用软件Revman 5.3对所检索文献进行Meta分析。结果:最终纳入23个研究,质量评价平均分数4.8。Meta分析结果显示,电针可显著性降低低密度脂蛋白(low density lipoprotein cholesterol,LDL-C)含量,差异有统计学意义[SMD-3.09,95%CI(-3.72,-2.45),P<0.000 01]。文献质量分析显示所纳入文献存在一定的发表性偏倚。结论:电针治疗高脂血症动物模型可显著降低LDL-C含量。

Objective：To systematically evaluate the efficacy and safety of electroacupuncture in experiments of animals with hyperlipidemia. Methods：With the key words of ＂ acupuncture＂ ＂ electroacupuncture＂ ＂ dyslipidemia＂ and ＂ hyperlipidemia＂,the computer retrieved the database of CNKI database,Wan Fang,VIP,CBM,Pub Med,EMBASE and Cochrane library before October 10,2017,and used the software Revman5. 3 to carry out Meta analysis. Results：Finally,23 studies were included,with an average score of 4. 8. The results of Meta analysis showed that electroacupuncture could significantly reduce the content of low density lipoprotein（ LDL-C）,and the difference was statistically significant [SMD-3. 09,95% CI（-3. 72,-2. 45）,P〈0. 000 01 ]. Literature quality analysis showed that there was a certain publication bias in the literature. Conclusion：Electroacupuncture can significantly reduce LDL-C content of animal model with hyperlipidemia.