甜梦口服液联合抗抑郁剂对男性抑郁症患者性功能的影响

Sexual function of depression in men with combination of Tianmeng Oral Liquid and anti-depressant

目的研究甜梦口服液联合抗抑郁剂对男性抑郁症患者性功能的影响。方法采用整群入组的方法,将2015年9月—2016年6月在河南中医药大学第一附属医院临床心理科门诊治疗并出现性功能障碍的男性抑郁症患者随机分为治疗组55例和对照组52例,治疗组给予甜梦口服液联合抗抑郁剂,对照组给予抗抑郁剂,治疗周期4周。采用国际勃起功能指数问卷(IIEF-6)和简明性功能自评量表(BSDSRS-5)、汉密尔顿抑郁量表(HAMD-17)、匹茨堡睡眠质量指数(PSQI)对病人的性功能、抑郁症状以及睡眠质量进行评价。结果治疗后两组患者HAMD评分较治疗前均明显下降(P<0.05)。治疗组患者HAMD评分比对照组降低更加明显,两组比较差异显著(P<0.05)。治疗后治疗组患者性功能较对照组改善显著(P<0.05),睡眠质量改善显著(P<0.05)。结论甜梦口服液联合抗抑郁药物帕罗西汀、西酞普兰可以有效改善男性抑郁症患者的性功能并显著改善抑郁症状。

Objective To observe the effect of Tianmeng Oral Liquid combined with depressant on sexual function of male patient with depression. Methods Male depression outpatients（107 cases） with sexual dysfunction in the processs of treatment in the clinical psychology of the first affiliated hospital of Henan university of Chinese medicine from september 2015 to June 2016 were randomly divided into the control group（55 cases） and treatment group（52 cases）. The patients in the control group were po administered with Escitalopram, 10—20 mg/d or Paroxetine, 20—40 mg/d. The patients in the treatment group were po administered with Tianmeng Oral Liquid of 40 m L/d on the basis of the control group. The patients in two groups were treated for four weeks. To evaluate sexual function, depressive symptoms, and sleeping quality by International index of erectile function（IIEF-6） and Conciseness function since the rating scale（BSDSRS-5）, Hamilton＇s depression scale-17（HAMD-17）, and Pittsburgh sleep quality index（PSQI）. Results HAMD scores were significantly decreased in both groups after treatment（P〈0.05）. HAMD scores of the treatment reduced more obviously than the control group, the difference between the two groups had statistical significance（P〈0.05）. Sexual function of the treatment group improved more significantly than the control after treatment（P〈0.05）. Sleeping quality of the treatment improved significantly compared with the control after treatment（P〈0.05）. Conclusion Tianmeng Oral Liquid combined with depressant Escitalopram, 10—20 mg/d or Paroxetine can increase the sexual function of men with depression effectively and improve depressive symptoms obviously.