中药凝胶贴膏基质选择及挥发油加入方式研究进展

Research progress on selection of matrix and adding methods of volatile oil in Chinese materia medica cataplasma

凝胶贴膏属于新型透皮给药载体,可以克服传统橡皮膏、黑膏药使用不便、刺激性强等缺点,是中药现代化的重要一环,但目前其发展被基质辅料种类、挥发性药物处理方式等关键因素制约。对2000—2017年与中药凝胶贴膏基质优化和挥发油处理方式有关的文献共254篇进行整理,以凝胶贴膏基质种类及辅料配比范围、优化基质配比的实验设计方法、凝胶贴膏中挥发油处理方式3个方面进行综述,并对其中存在的问题进行讨论,以期为后续研究提供借鉴。

Cataplasma is a new transdermal drug delivery carrier, playing a significant role in the modernization of Chinese materia medica（CMM）. It can overcome many shortcomings such as inconvenient use and intense irritation in traditional adhesive plaster and black plaster. However, the development of cataplasma is restricted by some crucial factors like the types of auxiliary materials and the processing ways of volatile medicine. A total of 254 articles related to CMM cataplasma optimization and the volatile oil treatment published from 2000 to 2017 were collected and sorted in this paper. The matrix types and excipients ratio scope, the experiment design method of optimized ratio of base material, and the processing ways of volatile oil in cataplasma were summarized, and then the existing problems in these three aspects mentioned above were discussed with view to giving reference for follow-up studies.