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芪玄抑甲宁对Graves病模型药效学研究 被引量:5

Pharmacodynamic Research of Qixuan Yijianing on Treatment for Models of Graves Disease
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摘要 目的:探讨芪玄抑甲宁对Graves病动物模型的药效学作用。方法:胫前肌注重组腺病毒复制Graves病动物模型,给药后观察小鼠外观行为,酶标仪检测实验小鼠血清中血清游离甲状腺素(FT4)和促甲状腺激素受体抗体(TRAb)的含量变化,并取甲状腺组织用于病理学检查。结果:芪玄抑甲宁对小鼠的外观行为、甲状腺组织病理具有改善作用,并对血清中FT4、TRAb均有回调作用。结论:芪玄抑甲宁对Graves病动物模型具有良好的治疗效果。 Objective:To study the pharmacodynamic effect of Qixuan Yijianing on animal models of Graves disease(GD). Methods:The animal models of GD reconstructed by injecting recombinant adenovirus,and observed the appearance and behavior of mice after administration. Then the changes of the level of free thyroxine(FT4)and anti-thyrotropin receptor antibody(TRAb)in serum were detected by microplate reader,and the thyroid tissue was taken for pathological examination. Results:Qixuan Yijianingcan improve the appearance,behavior and thyroid gland pathology of mice,and have a callback effect on the level of FT4 and TRAb in serum. Conclusion:Qixuan Yijianing has a good therapeutic effect on the animal models of GD.
作者 刘树民 甄喆 王可心 汪娜 张娜 杨智明 柳长凤 LIU Shumin;ZHEN Zhe;WANG Kexin;WANG Na;ZHANG Na;YANG Zhiming;LIU Changfeng(Center for Drug Safety Evaluation of Heilongjiang University of Chinese Medicine, Harbin 150040, Heilongjiang, China;Institute of Traditional Chinese Medicine, Heilongjiang University of Chinese Medicine, Harbin 150040, Heilongjiang, China)
出处 《辽宁中医药大学学报》 CAS 2018年第6期5-7,共3页 Journal of Liaoning University of Traditional Chinese Medicine
基金 国家自然科学基金项目(81302898) 黑龙江省教育厅科学技术研究项目(12541744) 黑龙江省青年科学基金项目(QC2012C038)
关键词 芪玄抑甲宁 GRAVES病 药效学 Qixuan Yifianing Graves disease pharmacodynamics
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