米力农对高龄老年舒张性心力衰竭者血清TNF-α、HCY、CystC的影响

The impact of Milrinone on the serum TNF-a, HCY, Cyst C of elderly persons with diastolic heart failure

目的探讨米力农对高龄老年舒张性心力衰竭者血清肿瘤坏死因子-α(TNF-α)、同型半胱氨酸(HCY)水平、半胱氨酸蛋白酶抑制剂C(CystC)水平的影响。方法采用随机抽样的方法选取2016年1月至2017年10月本院收治的80例高龄老年冠心病舒张性心力衰竭患者,随机将这些患者分为研究组和对照组,每组40例。给予对照组常规治疗,观察组在常规治疗基础上米力农泵入治疗,然后对两组患者治疗前、治疗7天后的血清TNF-α、HCY、CystC进行统计分析。结果研究组患者的总有效率92.5%(37/40)显著高于对照组70.0%(28/40)(P<0.05),治疗7天的左室射血分数(LVEF)、左心室短轴缩短率(FS)、舒张早期和晚期二尖瓣血流峰值(E峰、A峰)及E/A比值均显著高于对照组(P<0.05),治疗7天的血清TNF-α、HCY、CystC均显著低于对照组(P<0.05)。结论米力农能够有效改善老年舒张性心力衰竭者血清TNF-α、HCY、CystC水平。

Objective To investigate the impact of Milrinone on the serum TNF-a, HCY, CystC of elderly persons with diastolic heart failure.Methods 80 cases of elderly patients with coronary heart line diastolic heart failure in our hospital from January 2016 to October 2017 were selected by random sampling method.These patients were divided into study group and control group based on a random number table, each group had an average of 40 cases. Thepatients in the control group were given conventional treatment, while in the observation group were given Milrinone therapy based on the conventional treatment. The serum TNF-a, HCY, CystC before treatment, 7 days later of the two groups were statistically analyzed.Results The total efficiency of the study group 92.5%（37/40） was significantly higher than that of the control group 70.0%（28/40）（P〈0.05）.The LVEF, FS, E, E/A7 days later in the study group were significantly higher（P〈0.05）, the serum TNF-a, HCY, CystC 7 days laterin the study group were significantly lower than those in the control group（P〈0.05）. Conclusion Milrinone can improve the serum TNF-a, HCY, CystC of elderly persons with diastolic heart failure.