摘要
目的了解甘肃省兰州地区儿童发热出疹性疾病(Rash and fever illness,RFI)血清学和病原学特征,为麻疹控制提供依据。方法选择2016年10月1日-2017年9月30日兰州市某区7家医院就诊的0-14岁RFI患儿,对患儿血清标本采用酶联免疫吸附试验检测麻疹病毒IgM抗体,对患儿咽拭子标本采用PCR-荧光探针法检测麻疹病毒基因。结果兰州某区RFI患儿血清麻疹Ig M阳性率为11.6%(77/662),本地、流动人口分别为10.9%(60/552)、15.5%(17/110);咽拭子标本麻疹病毒H1a基因型检出率为18.9%(61/323),本地人口、流动人口分别为18.5%(50/271)、21.1%(11/52)。本地、流动人口病例中有麻疹疫苗免疫史分别占100%(476/476)、71.6%(78/109)。结论兰州地区RFI病例麻疹实验室确诊率流动人口高于本地人口,应加强流动人口疫苗接种工作。
Objective To determine serologic and etiologic characteristics of rash and fever illness( RFI)cases in a district of Lanzhou,and to provide evidence for strengthening measles and rubella control.Methods We selected 0-14 year old RFI cases from 7 hospitals in a district in Lanzhou that were reported between October 1,2016 and September 30,2017. We collected serum specimens for measles Ig M antibody detection by enzyme-linked immunosorbent assay( ELISA),and throat swabs for detection of measles virus genes by quantitative PCR fluorescence. Results Among all RFI cases,the measles Ig M sero-positivity rate was 11. 6%( 77/662); among local cases sero-positivity was 10. 9%( 60/552),and among migrant cases,sero-positivity was 15. 5%( 17/110). Among all RFI cases for which we had throat swabs,H1 a measles virus genotype was isolated from 18. 9%( 61/323); among local cases H1 a genotype was isolated from 18. 5%( 50/271),and among migrant cases,H1 a genotype was isolated from21. 1%( 11/52). All( 476/476) local cases and 71. 6%( 78/109) of migrant cases had received measles vaccine. Conclusions The proportion of lab-confirmed measles was higher among migrant RFI cases than among local RFI cases. Vaccination efforts for migrant children should be strengthened.
作者
王春萍
潘丽
杨茜
杨珍
杨玉兰
马兴铭
Wang Chunping;Pan Li;Yang Qian;Yang Zhen;Yang Yulan;Ma Xingming(College of Basic Medical Sciences, Lanzhou University, Lanzhou 730000, Gansu, China;Lanzhou Maternal and Child Health Hospital, Lanzhott 730000, Gansu, China)
出处
《中国疫苗和免疫》
北大核心
2018年第3期260-263,共4页
Chinese Journal of Vaccines and Immunization