非核糖体肽合成酶研究进展

Advances in the nonribosomal peptide synthetases

非核糖体肽合成酶催化合成结构和功能多样的非核糖体肽类化合物,包括20多种已上市的药物。本文重点对近年来在非核糖体肽合成酶结构域及其作用机制研究方面取得的进展,以及新发现的几种非常规装配模式,包括重复使用模块、模块跳跃、反式上载和A结构域串联进行综述,为寻找新的非核糖体肽类化合物及其新药研发提供理论依据。

Nonribosomal peptide synthetases（NRPS） catalyze the synthesis of nonribosomal peptide（NRP） compounds with structural and functional diversities, including more than 20 marketed drugs. This review focuses on the recent advances in the functional domains of NRPS and their mechanisms of action, as well as the unconventional assembly patterns such as iterative NRPS, module skipping, in trans aminoacylation and tandem adenylation domains. This review provides the theoretical basis for exploring new nonribosomal peptide compounds and the development of new drugs.