四磨汤联合水疗保健对新生儿黄疸免疫能力、黄疸指数及临床疗效的影响

Effect Analysis of Simo Decoction Combined with Hydrotherapy on Neonatal Jaundice,Jaundice Index and Immune Ability

目的：分析四磨汤联合水疗保健对新生儿黄疸免疫能力、黄疸指数及临床疗效的影响。方法：120例新生儿黄疸,其临床表现为面部、躯干黄染,还累及四肢、手心、足心均黄染。将患儿按随机数字法分为对照组和观察组。对照组患儿采用水疗保健的治疗方案,观察组在对照组的基础上增加口服四磨汤。治疗前、治疗5 d后,使用全自动生化分析仪和经皮胆红素仪测定患者的黄疸指数及血清C蛋白（CRP）、转铁蛋白（TRF）、免疫球蛋白A（IgA）及免疫球蛋白G（IgG）,统计患者的治疗效果。结果：治疗前,两组患儿的黄疸指数无明显差异（P〉0.05）;治疗后第5天,观察组的黄疸指数（55.23±8.19）μmol/L明显低于对照组（88.19±7.46）μmol/L;观察组黄疸消退时间（4.13±0.81）d明显低于对照组（5.27±0.89）d,差异具有统计学意义（P0.05）;治疗后第5天,观察组患儿的IgA、IgG及TRF含量明显高于对照组,CPR（8.25±1.26）mg/L明显低于对照组（10.34±1.17）mg/L,差异有统计学意义（P12 mL/dL的人数明显少于对照组,差异有统计学意义（P〈0.05）。观察组治疗的有效率90.00%（54/60）明显高于对照组治疗的有效率76.67%（46/60）,差异有统计学意义（P〈0.05）。结论：四磨汤联合水疗保健治疗新生儿黄疸,能明显改善患者的黄疸指数,有效改善患儿的免疫能力,具有明显的疗效和较高的安全性,值得临床借鉴推广。

Objective： To analyze the effect of Simo Decoction combined with hydrotherapy on neonatal jaundice,jaundice index and immune ability of clinical curative effect. Methods： A total of 120 cases of neonatal jaundice were randomly selected. The clinical features included yellow facial and trunk staining,as well as yellowing of the limbs,palms and feet. The children were divided into the control group and the observation group by random number method. The control group received treatment hydrotherapy and the observation group added Simo Decoction orally. Before treatment,5 days after treatment,automatic biochemical analyzer and transcutaneous bilirubin analyzer were used to detect the jaundice index and serum C reactive protein（ CRP）,transferrin（ TRF）,immunoglobulin A（ IgA） and immunoglobulin G（ IgG）.Results： Before treatment,there was no significant difference between the 2 groups of children with jaundice index（ P 〉0. 05）. Five days after treatment,the observation group＇s jaundice index（ 55. 23 ± 8. 19） μmol/L was significantly lower than the control group＇s（ 88. 19 ± 7. 46） μmol/L. The observation group＇s time jaundice was significantly lower than that of the control group,and the difference was statistically significant（ P〈 0. 05）. Before treatment,two groups＇ IgG,immune factors IgA,CPR and TRF showed no significant difference（ P〈 0. 05）. Five days after treatment,the observation group＇s IgA,IgG and TRF were significantly higher than that of the control group,and CPR was significantly lower than that of the control group,（ P〈 0. 05）. After 5 days of treatment,the observation group＇s serum bilirubin concentration was less than 8 mL/dL in 52 cases was significantly higher than that of the control group＇s 31 cases. The cases which serum bilirubin concentration was in 8-12 mL/dL or more than 12 mL/dL was less than that of the control group（ P〈 0. 05）. The effective rate of the observation group was 90%（ 54/60）,which was obviously higher than that of the control group＇s 76. 67%（ 46/60）（ P〈 0. 05）. Conclusion： Simo Decoction combined with hydrotherapy treatment of neonatal jaundice,can significantly improve the jaundice index and effectively improve children＇s immune ability. It is safe and has obvious curative effect,worthy of clinical promotion.