热淋清颗粒联合多沙唑嗪和左氧氟沙星治疗慢性细菌性前列腺炎的疗效观察

Efficacy Observation of Relinqing Granules Combined with Doxazosin and Levofloxacin in Treatment of Chronic Bacterial Prostatitis

目的：探讨慢性细菌性前列腺炎患者经热淋清颗粒联合多沙唑嗪和左氧氟沙星治疗后的效果。方法：76例慢性细菌性前列腺炎患者,采用随机数字表法分为对照组和观察组,38例对照组患者给予多沙唑嗪＋左氧氟沙星治疗,38例观察组患者则采用热淋清颗粒＋多沙唑嗪＋左氧氟沙星治疗。治疗1个月后,观察两组临床治疗效果、治疗前后前列腺液白细胞计数（EPS-WBC）、慢性细菌性前列腺炎症状评分（NIH-CPSI）以及血清炎性因子水平的变化情况。结果：经不同治疗后,观察组患者治疗总有效率（94.83%）明显高于对照组（82.76%）（P〈0.05）。观察组治疗后EPS-WBC（3．48±0．80）个、排尿障碍（2．87±0．67）分、疼痛或不适（5．41±1．43）分、生活质量（3．23±0．82）分与对照组治疗后EPS-WBC（8．52±0．83）个、排尿障碍（5．76±1．58）分、疼痛或不适（8．70±2．01）分、生活质量（5．78±1．94）分相比较，差异有统计学意义（P〈0．05）。观察组IL-2（103．29±27．65）pg／mL、CRP（6．21±1．65）mg／mL、TNF-γ（14．82±2．33）pg／mL指标水平均低于对照组IL-2（158．03±42．94）pg／mL、CRP（10．44±2．86）mg／mL、TNF-γ（23．76±6．32）pg／mL，差异有统计学意义（P〈0．05）。观察、对照两组不良反应发生率分别为6．90％、5．17％，两组均具有较良好的用药安全性，差异无统计学意义（P〉0．05）。结论：热淋清颗粒联合多沙唑嗪和左氧氟沙星治疗慢性细菌性前列腺炎临床疗效显著,能够有效改善EPS-WBC、NIH-CPSI评分以及血清炎性因子水平,治疗期间不良反应少,值得在临床上推广应用。

Objective： To investigate effect of Relinqing Granules combined with doxazosin and levofloxacin in the treatment of the patients with chronic bacterial prostatitis. Methods： 76 cases of chronic bacterial prostatitis patients,were randomly divided into the control group and the observation group. Thirty-eight cases in the control group were treated with doxazosin ＋ levofloxacin treatment and the observation group＇s 38 cases were treated with Relinqing Granule ＋doxazosin ＋ levofloxacin treatment. After 1 month treatment,two groups were observed prostatic fluid white blood cell count（ EPS-WBC）,the symptoms of chronic bacterial prostatitis score（ NIH-CPSI） and changes of serum inflammatory factors levels. Results： After treatment,the total effective rate of the observation group（ 94. 83%） was significantly higher than that of the control group（ 82. 76%）（ P〈 0. 05）. After treatment,the observation group＇s EPS-WBC（ 3. 48± 0. 80）,dysuria（ 2. 87 ± 0. 67）,pain or discomfort（ 5. 41 ± 1. 43）,quality of life（ 3. 23 ± 0. 82） after treatment were statistically significant compared with the control group＇s EPS-WBC（ 8. 52 ± 0. 83）,dysuria（ 5. 76 ± 1. 58）,pain or discomfort（ 8. 70 ± 2. 01）,quality of life（ 5. 78 ± 1. 94） %（ P〈 0. 05）. The observation group＇s IL-2（ 103. 29 ±27. 65） pg/mL,CRP（ 6. 21 ± 1. 65） mg/mL and TNF-γ（ 14. 82 ± 2. 33） pg/mL index were lower than the control group＇s IL-2（ 158. 03 ± 42. 94） pg/mL,CRP（ 10. 44 ± 2. 86） mg/mL and TNF-γ（ 23. 76 ± 6. 32） pg/mL. The difference was statistically significant（ P〈 0. 05）. The incidence of adverse reactions in the two groups was 6. 90% and 5. 17% respectively,and the two groups had better safety in medication and the difference was not statistically significant（ P〉 0. 05）. Conclusion： Relinqing Granules combined with doxazosin and levofloxacin in the treatment of chronic bacterial prostatitis can effectively improve the EPS-WBC,NIH-CPSI score and serum levels of inflammatory factors and less adverse reactions during treatment,worthy of clinical application.