麝香保心丸联合瑞舒伐他汀治疗冠心病心绞痛临床疗效及对血液流变学、血脂的影响

Clinical Efficacy of Shexiang Baoxin Pill Combined with Rosuvastatin in Treatment of Angina Pectoris and Influence on Hemorheology and Blood Lipid

目的：研究与分析麝香保心丸与瑞舒伐他汀联合治疗冠心病心绞痛患者的临床效果及对其血液流变学及血脂的影响。方法：冠心病心绞痛患者102例,按数字表法随机分为对照组48例与观察组54例。两组患者均予以常规治疗方案,在此基础上,对照组采用瑞舒伐他汀进行治疗,观察组则采用麝香保心丸联合瑞舒伐他汀进行治疗。对比两组患者治疗前后血液流变学情况、血脂水平及炎症因子水平变化情况。结果：经过治疗后,观察组全血黏度（10.02±4.53）m Pa·s、血浆黏度（1.78±0.02）m Pa·s、纤维蛋白含量（2.32±1.54）g/L、TC（6.57±1.84）mmol/L、TG（2.78±1.05）mmol/L、LDL-C（1.65±0.51）mmol/L、HDL-C（1.42±0.40）mmol/L、IL-1（30.82±7.69）mmol/L、IL-6（36.05±8.25）mmol/L、IL-10（33.35±5.27）mmol/L、TNF-α（38.75±6.40）mmol/L均明显优于对照组全血黏度（12.19±5.02）m Pa·s、血浆黏度（2.33±0.09）m Pa·s、纤维蛋白含量（3.32±1.38）g/L、TC（8.46±1.55）mmol/L、TG（3.30±1.09）mmol/L、LDL-C（2.33±0.38）mmol/L、HDL-C（3.05±0.44）mmol/L、IL-1（44.68±9.37）mmol/L、IL-6（49.96±9.96）mmol/L、IL-10（44.67±6.52）mmol/L、TNF-α（48.32±8.76）mmol/L,差异有统计学意义（P〈0.05）。结论：麝香保心丸联合瑞舒伐他汀可有效缓解冠心病患者心绞痛发作情况,改善其血流变及心肌功能,同时还有较优的降脂及抗炎作用,应用效果较优。

Objective： To study and analyze the clinical effect of Shexiang Baoxin Pill combined with rosuvastatin in the treatment of angina pectoris and the influence of hemorheology and blood lipid. Methods： Totally 102 patients with angina pectoris were selected and randomly divided into the control group（ n = 48） and the observation group（ n = 54） according to the digital table method. Two groups were given conventional treatment and the control group was treated with rosuvastatin and the observation group was treated with Shexiang Baoxin Pill combined with rosuvastatin. The changes of hemorheology,blood lipid and inflammatory factors were compared between two groups before and after treatment. Results： After treatment,the whole blood viscosity（ 10. 02 ± 4. 53） m Pa·s,plasma viscosity（ 1. 78 ± 0. 02） m Pa·s,Fibrin content（ 2. 32 ± 1. 54） g/L,TC（ 6. 57 ± 1. 84） mmol/L,TG（ 2. 78 ± 1. 05） mmol/L,LDL-C（ 1. 65 ± 0. 51） mmol/L,HDL-C（ 1. 42 ± 0. 40） mmol/L,IL-1（ 30. 82 ± 7. 69） mmol/L,IL-6（ 36. 05 ± 8. 25） mmol/L,IL-10（ 33. 35 ± 5. 27）mmol/L and TNF-α（ 38. 75 ± 6. 40） mmol/L of the observation group were significantly better than the control group＇s whole blood viscosity（ 12. 19 ± 5. 02） m Pa·s,plasma viscosity（ 2. 33 ± 0. 09） m Pa·s,Fibrin content（ 3. 32 ± 1. 38）g/L,TC（ 8. 46 ± 1. 55） mmol/L,TG（ 3. 30 ± 1. 09） mmol/L,LDL-C（ 2. 33 ± 0. 38） mmol/L,HDL-C（ 3. 05 ±0. 44） mmol/L,IL-1（ 44. 68 ± 9. 37） mmol/L,IL-6（ 49. 96 ± 9. 96） mmol/L,IL-10（ 44. 67 ± 6. 52） mmol/L,TNF-α（ 48. 32 ± 8. 76） mmol/L,and the difference was statistically significant（ P 〈 0. 05）. Conclusion： Shexiang Baoxin Pill combined with rosuvastatin can effectively relieve the patients with angina pectoris,improve the blood rheology and cardiac function,and have better lipid-lowering and anti-inflammatory effects.