体质指数与性别差异对浙江中北部农村居民慢性肾脏病患病率的影响

The effects of body mass index and gender difference on the prevalence of chronic kidney disease in rural residents in north-central of Zhejiang

目的探讨浙江中北部农村居民慢性肾脏病(chronic kidney disease,CKD)发病率与体质指数(body mass index,BMI)及性别差异的相关性。方法于2015年4—12月对浙江中北部(磐安县高二乡、海宁市永福村、海宁市许桥村、桐乡市路家园村)4个不同村落、118个村民小组内居住5年以上的18岁以上原住居民进行慢性肾脏病问卷调查,并进行体质指数(body mass index,BMI)、肾脏损伤指标及相关危险因素检测。结果经浙江省第六次人口普查数据中乡村地区人口经年龄性别分布标化后,在资料完整的1 627例居民中白蛋白尿(ACR)患病率为7.88%、肾小球滤过率(e GFR)下降患病率为2.37%,CKD患病率为9.21%,且女性患病率高于男性;根据体质量判断标准,共筛查出体重正常者851例,体重过低者54例,超重者578例,肥胖者144例,其中:BMI在18.5~23.9 kg/m2ACR及CKD检出率较高;二分类Logistic回归分析显示,性别、年龄、高血压史、空腹血糖、尿酸、BMI均是CKD的独立危险因素。结论浙江中北部四个村落农村居民CKD患病率随BMI增加有增长趋势,且女性患病率高于男性。

Objective To observe the effects of body mass index （BMI） and gender difference on the prevalence of chro- nic kidney disease （CKD） of rural residents in north-central of Zhejiang. Methods In four different villages of north- central of Zhejiang, 118 villagers groups of inhabitants （more than 5 years） age more than 18 years old were sampled to receive a questionnaire survey in chronic kidney disease, and to test BMI, kidney damage index and related risk factors. Results Screening from 1 627 cases of residents with complete information, there were 851 cases of normal weight, 54 patients in low weights groups, 578 cases of overweight, 144 cases of obesity. Peak incidence of ACR and CKD in pa- tients with BMI of 18.5 -23.9 kg/m2. According to the data of rural population distribution in the sixth census of Zhe- jiang province and after age gender standardized, ACR prevalence was 7.88% , eGFR decline prevalence was 2.37% , the total prevalence of CKD was 9.21% , Binary classification Logistic regression analysis showed that gender, age, histo- ry of hypertension, FBG, UA, BMI were the independent risk factors of chronic kidney disease. Conclusion The prev- alence of CKD of rural residents in north-central of Zhejiang has a growth trend as BMI increased, the prevalence of fe- male was significantly higher than male.