参芪健胃颗粒对慢性萎缩性胃炎患者胃动素、胃泌素及免疫功能的影响

Effect of Shenqijianwei Granule on chronic atrophic gastritis of motilin and gastrin and immune function

目的探讨参芪健胃颗粒对慢性萎缩性胃炎患者胃动素、胃泌素及免疫功能的影响。方法将2015年3月—2016年9月丽水市中医院收治的68例慢性萎缩性胃炎患者分为观察组和对照组,每组34例。对照组给予常规西医对症治疗。观察组在对照组基础上,给予参芪健胃颗粒。对比2组治疗前后中医症状评分。检测2组患者治疗前后胃动素、胃泌素及T淋巴细胞的变化。结果观察组的疗效显著优于对照组,差异有统计学意义(Z=2.421,P<0.05);2组治疗后胃脘疼痛、胃脘痞胀、倦怠乏力、食少纳呆、总评分显著降低(均P<0.05);治疗后,观察组的胃脘疼痛、胃脘痞胀、倦怠乏力、食少纳呆、总评分显著低于对照组,差异有统计学意义(均P<0.05);观察组治疗后CD4、CD4/CD8显著升高,CD8显著降低(P<0.05);治疗后,观察组的CD4、CD4/CD8显著高于对照组,CD8显著低于对照组,差异有统计学意义(均P<0.05);2组治疗后胃动素、胃泌素显著升高(均P<0.05);治疗后,观察组的胃动素、胃泌素显著高于对照组,差异有统计学意义(均P<0.05)。结论参芪健胃颗粒能提高慢性萎缩性胃炎患者的胃动素、胃泌素的水平,改善免疫功能。

Abstract Objective To investigate the effect of Shenqijianwei Granule on chronic atrophic gastritis of motilin and gas- trim and immune function. Methods Sixty-eight patients with chronic atrophic gastritis were divided into observation group and control group, each group of 34 cases. The control group was given conventional western medicine symptomatic treatment. The observation group in the control group based on the given Shenqijianwei granules. Comparison of the two groups before and after treatment of TCM symptom score. Changes of motilin and gastrin and T lymphocytes in the two groups before and after treatment were detected. Results The curative effect of the observation group was significantly better than that of the control group. The difference was statistically significant （Z = 2. 421, P 〈 0.05 ）. Two groups after the treatment of epigastric pain, epigastric fullness distension, lassitude, anorexia, total score decreased significantly （P 〈 0.05 ）. After treatment,the observation group of epigastric pain, epigastric fullness distension, lassitude, anorexia, the total score was significantly lower than the control group. The difference was statistically significant （ P 〈 0.05 ）. Af- ter treatment, CD4 and CD4/CD8 in the observation group were significantly increased, CD8 was significantly lower （ P 〈 0.05）. After treatment, the CD4 and CD4/CD8 in the observation group were significantly higher than those in the control group, CD8 was significantly lower than that in the control group. The difference was statistically significant （P 〈 0.05 ）. The two groups after treatment of motilin and gastrin increased significantly （ P 〈 0. 05 ）. After treatment, the ob- servation group of motilin and gastrin was significantly higher than the control group. The difference was statistically sig- nificant （P 〈 0. 05 ）. Conclusion Shenqijianwei granule can improve the patients of chronic atrophic gastritis of motilin and gastrin levels, improve immune function.