氨己烯酸治疗婴儿痉挛的疗效和安全性观察

Efficacy and Safety of Vigabatrin in the Treatment of Infantile Spasms

目的:评价氨己烯酸治疗婴儿痉挛的疗效和安全性。方法:选择2015年4月至2016年9月于韩国Severance儿童医院诊治的46例婴儿痉挛患者给予口服氨己烯酸治疗,起始剂量为50 mg/(kg·d),第2天加至100 mg/(kg·d),如症状控制明显,则继续应用3~6个月,定期复查脑电图;如1周后无效,则加量至150 mg/(kg·d),应用3~6个月,随访时间为3~10个月。结果:氨己烯酸单药治疗总有效率为67.4%(31/46),无发作率为19.6%(9/46),复发率6.5%(3/46),短期不良反应主要为嗜睡、纳差、激惹、多动。结论:氨己烯酸治疗婴儿痉挛症效果显著,复发率低,不良反应通常在早期出现。

Objective： To evaluate the efficacy and safety of vigabatrin（ VGB） in the treatment of infantile spasms（ IS）. Methods：Forty-six IS patients admitted into Severance Children＇s Hospital from April 2015 to Sept. 2016 were given oral VGB at an initial dose of 50 mg/（ kg·d）,the next day added to 100 mg/（ kg·d）; if the symptom control was significant,the application would be continued for 3 ～ 6 months,and the regular review of EEG was conducted. If it was not effective after 1 week,the dosage would be added to150 mg/（ kg·d）,with application of 3 ～ 6 months and followed up for 3 ～ 10 months. Results： The total effective rate of monotherapy of VGB was 67. 4%（ 31/46）,the seizure free was 19. 6%（ 9/46） and the relapse rate was 6. 5%（ 3/46）. Short-term adverse drug reactions were mainly performed as drowsiness,anorexia,irritability and hyperactivity. Conclusion： The effects of VGB in the treatment of IS is significant,and the relapse rate is low with the side-effects usually appearing early.