赭曲霉毒素A的电化学适体传感检测

Electrochemical Aptasensor for Detection of Ochratoxin A

赭曲霉毒素A(OTA)是一类主要由曲霉属和青霉属等真菌产生的小分子有毒次级代谢产物,广泛存在于食品、农产品和动物饲料中,具有强烈肝毒性、肾毒性、致畸和致突变等作用,亦是ⅡB类致癌物。鉴于OTA污染的普遍性和危害性,本文就目前OTA的常用检测方法进行概述和比较,重点阐述新型电化学适体传感技术在OTA检测方面的相关应用。全面综述了构型变换型、亲合型以及混合型OTA电化学适体传感器的原理、优缺点及最新研究进展,并对OTA电化学适体传感器的未来发展方向提出展望,为电化学适体传感器的深入研究与应用提供参考。

Ochratoxin A（ OTA） is a toxic secondary metabolite of small molecular weight mainly produced by Aspergillus and Penicillium species,which are widely found in food,agricultural products and animal feed. It has strong hepatotoxicity, nephrotoxicity, teratogenic and mutagenic effects, and is also a class Ⅱ B carcinogens. In viewof OTA ＇s universality and harmfulness,the present situation of the commonly used detection methods of OTA is summarized and compared in this paper. Specifically,the application of newelectrochemical aptasensor in OTA detection is mainly described. OTA electrochemical aptasensors are divided into three categories： configuration transformation type, affinity type and hybrid type. Their respective principles,characteristics and the latest research progress are discussed in detail. Furthermore,the summary of the future directions and the potential applications are given,which provides reference for the further research and application of OTA.