术后辅助化疗对胰腺癌根治术后患者生存期的影响

Effect of postoperative adjuvant chemotherapy on the survival in patients underoing radical surgery for pancreatic cancer

目的探讨术后辅助化疗对胰腺癌根治术后患者生存期的影响。方法选取2008年2月至2015年2月间我院收治的70例胰腺癌患者进行回顾性分析,将使用氟尿嘧啶进行化疗的35例胰腺癌患者纳入研究组,将采取保守治疗不需要进行任何放化疗治疗的35例患者纳入对照组。治疗疗程结束后,随访并比较两组患者在6个月、10个月、14个月、18个月、22个月以及>22个月时的存活例数。结果研究组在治疗疗程结束后6个月、10个月、14个月、18个月、22个月及>22个月时的生存例数为35例、27例、21例、15例、10例及5例,对照组在这6个时间段的生存例数为32例、20例、12例、9例、4例及0例,研究组各时间段的生存率均高于对照组,差异均有统计学意义(均P<0.05)。结论对胰腺癌根治术后患者进行辅助化疗在一定程度上可延长胰腺癌患者的生存期。

Objective To study the effect of postoperative adjuvant chemotherapy on the survival in patients with pancreatic cancer after operation. Methods From February 2008 to February 2015,70 patients with pancreatic cancer who were treated at Nanjing Tongren Hospital School of Medicine,Southeast University were selected and divided into a study group and a control group with 35 patients in each group.The study group received chemotherapy with fluorouracil and the control group received conservative treatment without radiochemotherapy. After thetreatment,patients were followed up and the number of survivors at the 6,10,14,18 and 22 months,and 〉22 months in the two groups was recorded and compared.Results The number of survival cases was 35,27,21,15 and 5 in the study group and 32,20,12,9,4,and 0 in the control group at at the 6,10,14,18 and〉 22 months,and 22 months after the treatment.The survival rate at each time point was higher in the study group than in the control group（ all P〈 0. 05）.Conclusion Postoperative adjuvant chemotherapy can extend the survival to a certain extent in pancreatic cancer patients undergoing radical eradication.