系统性红斑狼疮与自身抗体

Systemic Lupus Erythematosus and Autoantibody

系统性红斑狼疮(SLE)是弥漫性结缔组织病的"原型",也是自身免疫性疾病的代表。SLE患者及动物模型中可见多种自身抗体。其中部分参与炎症过程及组织损伤。自身抗体介导了SLE的病理过程,可直接识别抗原引起组织损伤,也可以通过形成免疫复合物沉积于组织导致损伤。本文就系统性红斑狼疮常见自身抗体,以及这些抗体在疾病诊断、预后判断中的作用进行综述,并探讨自身抗体在SLE发病过程中所扮演的角色。

Systemic lupus erythematosus（SLE） is a prototype of diffuse connective tissue disease,and also a representative of autoimmune diseases. Multi-antibodies were found in SLE patients and animal models. It is understood that partial antibodies play an important role in the pathogenesis of the disease. The antibodies may recognize the specific antigens, therefor, cause the inflammation and tissue damage, or through the antigenantibody complex way to induce tissue damage. This review introduces the common autoantibodies in systemic lupus erythematosus, and the role of these autoantibodies in the diagnosis and prognosis of the disease. The mechanisms of antibody induced pathogenesis are also introduced in this review.