新生儿红斑狼疮的诊治

Diagnosis and Treatment of Neonatal Lupus Erythematosus

新生儿红斑狼疮是一种少见的由母体Ro/La抗体引起的被动免疫性疾病。临床可出现婴儿暴露部位的环形红斑或斑块、先天性心脏传导阻滞,少数可见肝脏、造血系统及神经系统的累及。该病可在出生后6~8个月随母体血清抗体消失而症状逐渐消失。孕期管理、患儿皮疹外用激素、监测心脏功能等是治疗该病的关键。

Neonatal lupus erythematosus is a rare immune disease caused by the passive transfer of maternal Ro/La antibody. The disease presents as annular erythema or plaques in the exposed skin and congenital heart block, visceral damage may coexist. Usually, the symptom will disappear in 6～8 months after birth with the clearance of Ro/La maternal antibody. Pregnancy management, topical steroids treatment for rash and cardiac function monitoring are the key for treatment.