γδ T细胞与肿瘤免疫治疗

γδ T cells and cancer immunotherapy

γδ T细胞是一类在人体先天性和过继性免疫反应中均起重要作用的独特免疫细胞亚群。它们识别抗原不受主要组织相容性抗原限制，具有显著的肿瘤细胞杀伤作用，因此利用γδ T细胞作为抗肿瘤免疫反应的效应细胞已引起了广泛关注。现对近年γδ T细胞在肿瘤免疫治疗领域的研究，尤其是在几种常见妇科肿瘤的实验研究进行综述。

γδ T cells have been well recognized as a unique cell population that is actively involved in both innate and adoptive immunity of bodies. The features of γδ T cells, such as their major histocompatibility complex independent antigen recognition and their cytotoxic effects to tumor cells, make them as promising candidates used for cancer immunotherapy. There is a strong interest in developing γδ T cell-based immunotherapy for clinical application in treating cancer patients. This review discusses the progress of recent studies related to the γδ T cells and cancer immunotherapy, with an emphasis on the main characteristics of γδ T cells in several types of gynecologic tumors.