黛力新在难治性胃食管反流病治疗中的效果研究

Effect research of Deanxit for the treatment of refractory gastroesophageal reflux disease

目的研究氟哌噻吨美利曲辛片(黛力新)在难治性胃食管反流病治疗中的效果。方法 72例难治性胃食管反流病患者,随机分为观察组与对照组,每组36例。对照组采用埃索美拉唑联合莫沙必利进行常规治疗,观察组在对照组基础上加用黛力新进行治疗。比较两组患者治疗效果、汉密尔顿抑郁量表(HAMD)评分、汉密尔顿焦虑量表(HAMA)评分及治疗前后耐性量表(RDQ)评分。结果观察组患者总有效率为91.67%(33/36),高于对照组的72.22%(26/36),差异具有统计学意义(χ~2=4.60,P<0.05)。治疗后,观察组RDQ评分为(5.20±2.01)分低于对照组的(11.69±3.78)分,差异具有统计学意义(P<0.05)。观察组患者HAMD、HAMA评分分别为(10.63±6.78)、(10.13±5.37)分均低于对照组的(24.26±10.51)、(18.64±10.58)分,差异具有统计学意义(P<0.05)。结论对难治性胃食管反流病患者加用黛力新治疗能够增强其疗效,提高治疗效果,减轻患者抑郁、焦虑症状,具有临床价值。

Objective To explore the effect of Flupentixol and Melitracen Tablets （Deanxit） for the treatment of refractory gastroesophageal reflux disease. Methods A total of 72 patients with refractory gastroesophageal reflux disease were randomly divided into the observation group and the control group, 36 cases in each group. The control group was given Esomeprazole combined with Mosapride for routine treatment, the observation group was given Deanxit for treatment on the basis of control group. The treatment effect, Hamilton Depression Rating Scale （HAMD） score, Hamilton Anxiety Scale （HAMA） score and Reflux Diagnostic Questionnaire （RDQ） score before and after treatment between two groups were compared. Results The total effective rate of observation group was 91.67% （33/36）, which was significantly higher than 72.22% （26/36）, the difference was statistically significant （χ2=4-60, P〈0.05）. After treatment, the RDQ score of observation group was （5.20± 2.01） scores, which was significantly lower than （11.69 ±3.78） scores of control group, the difference was statistically significant （P〈0.05）. The scores of HAMD and HAMA of observation group were （10.63 ±6.78） scores and （10.13 ± 5.37） scores, which were significantly lower than （24.26 ± 10.51） scores and （18.64 ± 10.58） scores of control group, the differences were statistically significant （P〈0.05）. Conclusion The treatment of refractory gastroesophageal reflux disease patients with Deanxit can enhance the curative effect, improve the therapeutic effect, reduce the symptoms of depression and anxiety, and has better clinical value.