脑得康治疗急性缺血性卒中的疗效分析

Efficacy of Naodekang decoction on acute ischemic stroke

目的探讨中药制剂脑得康治疗急性缺血性卒中的作用机制。方法选取山东省胶州市人民医院神经外科急性缺血性卒中患者362例,分为治疗组和对照组各181例。对照组给予常规药物治疗,治疗组在常规治疗加用脑得康。对比两组治疗前后卒中量表评分及BI评分,两组死亡率、不良反应发生情况及并发症。结果治疗前两组患者的神经机能缺损程度不显著(P>0.05),治疗后均有明显下降(P<0.01),且治疗组与对照组比较差异有统计学意义(P<0.01);治疗组和对照组治疗前BI评分分别为52.34±11.52分、53.14±12.57分比较差异无统计学意义(P>0.05);治疗组和对照组治疗后BI评分分别为82.42±16.58分、73.47±15.57分,比较差异有统计学意义(P<0.05);治疗组和对照组死亡率分别为8.84(16/181)、18.23%(33/181),比较差异有统计学意义(P<0.05);治疗组和对照组并发症发生率分别为3.31%、2.21%,比较差异无统计学意义(P>0.05)。结论在常规治疗基础上,添加脑得康治疗可以更好地改善AIS患者的预后。

Objective To explore the mechanism of the treatment of acute ischemic stroke by the Chinese medicine preparation of nidekang. Methods A total of 362 patients with acute ischemic stroke in the Department of neurosurgery in our hospital were divided into the treatment group and the control group, with 181 cases in each group. The control group was given conventional drug treatment, while the treatment group was given conventional treatment plus Naodekang. The stroke scale score and BI score before and after treatment were compared between the two groups, and the mortality rate, adverse reactions and complications of the two groups were compared. Results The difference of nerve function defect degree in two groups were not significantly different before treatment （ P 〉 0.05 ） and were significantly decreased after treatment （ P 〈 0. 01 ）. The BI scores of two groups before treatment were （52. 34 ± 11.52 ） and （53. 14 ± 12. 57 ） without the significantly difference （P 〉0. 05）. The BI scores of two groups after treatment were （82. 42 ±16. 58） and （73.47± 15.57） with the significantly difference （P 〈 0. 05 ）. The morality rates of two groups were 8.84% （16/181） and 18.23% （33/181）, respectively. There was a significant difference between two groups （P 〈0. 05）. The complication rates of two groups were 3.31% and 2. 21%. There was no significant difference （ P 〉 0. 05 ）. Conclusion The prognosis of patients with acute cerebral ischemia can be improved by Naodekang on the basis of conventional therapy.