心肌细胞能量代谢调控研究进展

Progress in energy metabolism regulation of cardiomyocytes

研究伴随物质代谢过程中能量的释放、转移、储存和利用已经有上百年历史。心脏是能量代谢相对活跃的器官,有研究表明每天心脏三磷酸腺苷(ATP)的转化量是其体质量的15~20倍。糖尿病心肌病、缺血性心肌病、肥厚性心肌病及扩张性心肌病等都与心肌细胞能量代谢紊乱息息相关,因此,研究心肌细胞能量代谢过程及其调控机制,对上述疾病的治疗具有重要的指导意义。近年仍然有不少学者在此方面进行了深入研究,本文对这些研究的结果做以总结,分别从底物的选择、糖代谢及脂代谢等方面进行综述。

Research on the release, transport, storage, and use of energy in the process of metabolism has been conducted for hundreds of years. The heart is relatively active among the energy metabolism organs and studies have shown that the daily conversion quantity of heart ATP is 15-20 times of its weight. Diabetic cardiomyopathy, ischemic cardiomyopathy, hypertrophic cardiomyopathy, dilated cardiomyopathy, and many other diseases are closely related to myocardial cell energy metabolism disorders. Research on myocardial cell energy metabolism and its regulation mechanism is of important guiding significance for the treatment of these diseases. In recent years, many scholars have conducted in-depth studies in this regard and this article summarizes findings from the choice of substrate, sugar metabolism, and lipid metabolism.