右美托咪啶预防小儿腹腔镜手术苏醒期躁动的临床研究

Clinical study on dexmedetomidine for preventing emergence agitation in children with laparoscopic surgery

目的探讨右美托咪啶预防小儿腹腔镜手术苏醒期躁动的临床效果。方法选取接受腹腔镜手术治疗的70例患儿作为研究对象，随机分为两组，每组35例。观察组给予右美托咪啶进行镇静治疗，对照组给予等量氯化钠注射液。比较两组患儿躁动苏醒指标和镇静评分程度。结果对照组苏醒时间明显短于观察组，躁动评分和躁动发生率明显高于观察组，差异有统计学意义（P〈0．05）；两组拔管后1h的Ramsay镇静程度评分比较，差异未见统计学意义（P〉0．05）；对照组拔管后2、3、4h的Ramsay镇静程度评分明显低于观察组，差异有统计学意义（P〈0．05）。结论右美托咪啶能有效预防小儿腹腔镜手术苏醒期躁动的发生，镇静效果显著，正确使用有利于患儿早日恢复健康，值得临床推广应用。

Objective To investigate the clinical effect of dexmedetomidine on preventing emergence agitation in children with laparoscopic surgery. Methods Seventy children with laparoscopic surgery were randomly divided into two groups, with 35 cases in each group. The patients in the observation group were given sedation therapy with dexmedetomidine, while the patients in the control group wer given the same dose of saline. The indexes of emergence agitation and scores of sedation degree were compared between the two groups. Results The awakening time of control group was shorter than that of observation group, the agitation score and incidence of agitation was higher than those of the observation group （P 〈 0. 05） ; after extubation for 1 h, there was no significant difference in the scores of Ramsay sedation degree between the two groups （ P 〉 0. 05 ） ; after extubation for 2 h, 3 h and 4 h, the scores of Ramsay sedation degree of the control group were lower than those of the observation group （ P 〈 0. 05 ）. Conclusions Dexmedetomidine can effectively prevent emergence agitation in children with laparoscopic surgery and has significant sedation effects, which can promote the early recovery of children, and is worthy of clinical promotion and application.