影响原发性局灶节段性肾小球硬化预后的因素

Prognostic factors in patients with primary focal segmental glomerulosclerosis

局灶节段性肾小球硬化(FSGS)是一类常见的临床病理综合征,临床上以大量蛋白尿或肾病综合征为主要表现,病理学特征性表现是局灶性、节段性、非增殖性毛细血管袢硬化和足细胞损伤。部分患者对于糖皮质激素和免疫抑制剂治疗反应性较差导致预后不佳,最终进展为终末期肾病。若能在早期对FSGS患者预后相关的各个因素进行分析,将有助临床医师综合判断其预后,并指导治疗方案。本文将分别从病理、临床、基因及治疗等四个层面提取与原发性FSGS预后相关的因素,并就这些因素展开探讨。

Focal segmental glomerulosclerosis（ FSGS） is a common clinical pathological syndrome,massive proteinuria or nephrotic syndrome is the presenting symptom.Focal,segmental,non proliferative capillary loops sclerosis and podocyte injury are the typical pathologic manifestations.Not all FSGS patients respond well to treatments,which may lead to a bad prognosis.Analysis of factors relate with prognosis,will help clinicians to judge the outcome of patients with FSGS and guide the correct treatment.In this summarize,we will sort out the factors in pathology; clinical parameters; genetic variation and treatment in primary FSGS patients.