肾移植后轻链沉积病

Light chain deposition disease after renal transplantation

中年男性患者,肾移植术后血清肌酐升高,中等量蛋白尿和少量镜下血尿,肾活检组织学为肾小球结节样病变,免疫病理κ轻链弥漫分布于肾小球系膜区、毛细血管袢,肾小管基膜和间质血管壁,超微结构观察肾小球系膜区、毛细血管袢基膜内侧、肾小管基膜外侧、间质及小动脉壁见细颗粒状电子致密物沉积,诊断为移植肾轻链沉积病。

A 49-year-old man presented with renal insufficiency,moderate proteinuria and mild hematuria 2 years after renal transplantation. Renal biopsy showed glomerular nodular lesions,with κ light chain diffusely distributed in the mesangial area,GBMs,TBMs and vessel walls.The final diagnosis was light chain deposition disease in renal graft.