苁蓉通便汤治疗阳虚便秘临床观察

Clinical Observation of Congrong Tongbian Decoction in Treating YANG Deficiency Type Constipation

目的:探讨苁蓉通便汤治疗阳虚便秘的临床疗效。方法:将符合标准的80例临床明确诊断为阳虚便秘的患者随机分为2组。对照组40例口服莫沙必利5mg,治疗9天;治疗组40例口服苁蓉通便汤治疗,先用小剂量肉苁蓉(10g)加入苁蓉通便汤治疗3天,再用中剂量肉苁蓉(20g)加入苁蓉通便汤治疗3天,后用大剂量肉苁蓉(30g)加入苁蓉通便汤治疗3天;9天后观察疗效,包括主要症状及排便评分等情况。结果:Wexner便秘评分比较,治疗组优于对照组,差异具有显著统计学意义(P<0.01)。KESS排便评分比较,肉苁蓉不同剂量组均能缩短阳虚便秘患者首次排便的时间,中、高剂量组与对照组比较差异显著有统计学意义(P<0.01);小剂量组与对照组比较差异有统计学意义(P<0.05)。结论:临床研究结果证实,苁蓉通便汤可以改善老年阳虚便秘患者的排便质量,缩短排便时间、减少排便时的疼痛及其他伴随症状,而且随着肉苁蓉剂量的增加出现令人满意的疗效。

Objective： To explore the clinical efficacy of Congrong Tongbian decoction in treating yang deficiency constipation. Methods： Eighty patients who met the criteria for a clinical diagnosis of constipation were randomly divided into two groups. In the control group, 40 patients received oral mosapride 5 mg for 9 days. Forty patients in the treatment group were treated with oral Congrong Tongbian decoction. They were first treated with a small dose of Cistanche（10 g） for 3 days and then treated with Congrong Tongbian decoction（20 g） for 3 days. A large dose of Cistanche（30 g）was added toCongrong Tongbian decoction for 3 days. After 9 days, the curative effect was observed, including the main symptoms and defecation scores. Results： The comparison of Wexner＇s constipation scores in the treatment group was superior to the control group, and the difference was statistically significant（P〈0.01）. Comparing the KESS defecation scores, different doses of Cistanche could shorten the time of first defecation in patients with constipation due to Yang deficiency, and the difference between the middle and high-dose groups and the control group was statistically significant（P〈0.01）. The difference between the low-dose group and the control group was statistically significant（P〈0.05）.Conclusion： Clinical studies have confirmed that Congrong Tongbian decoction can improve the defecation quality,shorten the defecation time, reduce the pain during defecation and other accompanying symptoms in patients with Yang deficiency constipation, and has a satisfactory therapeutic effect with increasing dose of Cistanche.