卵巢超声检查与骨龄指数在性早熟女童中的特征分析

Analysis of characteristics of ovarian ultrasound and bone age index in girls with precocious puberty

目的了解性早熟(precocious puberty)女童的卵巢超声检查结果与骨龄指数(BAI)的变化及特征。方法 120例性早熟女童,经促性腺激素释放激素类似物(GnRHa)激发试验确诊中枢性性早熟[ICPP(真性性早熟)]82例患儿为观察组,外周性性早熟[PPP(假性性早熟)]38例为对照组,统计并比较两组卵巢超声检查结果与骨龄指数的变化及特征。结果观察组卵巢容积为(3.46±0.98)ml、骨龄指数为(1.22±0.28),均大于对照组的(3.01±0.88)ml、(1.00±0.38),差异有统计学意义(P<0.05)。观察组卵巢内直径>4 mm且卵泡个数>4所占比例明显高于对照组,差异有统计学意义(P<0.05)。结论卵巢超声检查结果中卵巢容积、卵巢内直径>4 mm且卵泡个数>4的人数与骨龄指数对于早期诊断ICCP女童和PPP女童有很高的参考价值,对于卵巢超声检查结果和骨龄指数异常的女童应尽快进行GnRHa激发试验确诊,以便早发现早治疗。

Objective To understand the changes and indications of ovarian ultrasound results and bone age index（BAI） in girls with precocious puberty. Methods 120 girls with precocious puberty in our hospital were selected as research objects, 82 cases who were diagnosed as central precocious puberty（ICPP, true precocious puberty） by the gonadotropin releasing hormone（GnRHa） provocation test were selected as observation group, 38 cases with peripheral precocious puberty（PPP, precocious precocious puberty） were selected as control group.The changes and indications of ovarian ultrasound results and BAI between the two groups were gathered statistics and compared. Results The ovarian volume and bone age index of observation group were（3.46±0.98） ml and（1.22±0.28） respectively, which were significantly higher than（3.01±0.88） ml and（1.00±0.38） of control group, the differences were statistically significant（P〈0.05）. The proportion of intra ovarian diameter 〉4 mm and follicles 〉4 in observation group were significantly higher than those in control group, the differences were statistically significant（P〈0.05）. Conclusion In the ultrasound results, the value of ovarian volume, number of intra ovarian diameter 〉4 mm and follicles 〉4, and bone age index play important roles in early diagnosis of ICCP girls and PPP girls. For female patients with abnormal ovarian ultrasound and bone age index, the diagnosis of GnRHa stimulation test should be carried out as soon as possible in order to find early treatment.