应激在肠易激综合征致病机制中的作用

Role of stress in pathophysiology of irritable bowel syndrome

肠易激综合征(irritable bowel syndrome,IBS)是世界上最常见的功能性胃肠道紊乱疾病之一,以慢性间歇性腹痛,结肠动力障碍及排便习惯改变为特点,影响着大量患者的生活.内脏敏感性和消化道通透性增高是IBS中的重要病理生理机制但IBS确切的致病机制仍不清楚,目前认为涉及多种因素.精神心理因素尤其是应激在IBS的发生、发展和调节中占重要地位.本文综述了应激与IBS动物模型的关系以及应激在IBS内脏高敏、消化道高通透性机制中的作用,以期为进一步研究IBS的发病机制提供参考.

Irritable bowel syndrome（IBS）, one of the most common functional gastrointestinal disorders in the world, is characterized by chronic intermittent abdominal discomfort and colon dysmotility with altered bowel habits, significantly impacting patients＇ quality of life. The pathophysiology of IBS remains incompletely understood although some contributing factors have been identified. Increased visceral sensitivity and intestinal permeability may play an important role in the pathophysiology of IBS. Psychological factors, especially stress, play an important role in the occurrence, development, and regulation of IBS. To facilitate further research of IBS, this review focuses on the relationship between stress and IBS in animal models, as well as the role of stress in increased visceral sensitivity and intestinal permeability in IBS.