帕利哌酮缓释片的临床研究进展

Clinical study of paliperidone sustained release tablets

帕利哌酮缓释片是一种新型的非典型抗精神病药物,是一项全球性的首创以突破性口服药物传递系统(OROS)专利型渗透泵控释技术研发而成的治疗精神分裂症药物,是利培酮代谢后的活性产物。目前,帕利哌酮缓释片广泛应用于精神科,随着该药在临床治疗中广泛应用,与其他非典型抗精神病药相比,学者对该该药的研究越来越丰富。本文总结了近年来帕利哌酮缓释片对儿童、青少年、老年患者和女性内分泌等方面的影响,现综述如下。

Paliperidone sustained release is a new type of atypical antipsychotics,it is a global initiative work which research and develop from breakthrough OROS patent type osmotic pump controlled release technology,is the activity product of risperidone metabolites. It is widely used in psychiatric clinic,with the extensive application of clinical risperidone,compared with other atypical antipsychotics,more and more scholars have studied the drug. This article reviews the effects of parripidone sustained-release tablets on children and adolescents,elderly patients and female endocrine in recent years.