胱抑素C与2型糖尿病患者体质量指数的相关性分析

Correlation between serum cystatin C level and different body mass index in patients with type 2 diabetes mellitus

目的探讨胱抑素C(Cys C)水平与2型糖尿病(T2DM)患者不同体质量指数(BMI)的相关性。方法根据2000年WHO亚太地区成人肥胖标准,按BMI 25 kg/m2、BMI 28 kg/m2为切点,将160例T2DM患者分为正常体质量(NW)组88例、超重(OW)组42例及肥胖(OB)组30例,收集各组临床资料及生化指标。T2DM不同BMI的影响因素行Spearman相关分析及二元Logistic回归分析。结果 T2DM-OB组、T2DM-OW组血清Cys C水平均显著高于T2DM-NW组,以T2DM-OB组最高(P<0.05或P<0.01)。T2DM-NW/OW/OB与BMI、高血压史、ALT、AST、TC、TG、LDL-C、Apo B及Cys C呈正相关(P<0.05或P<0.01)。二元Logistic回归分析显示,ALT、TG、LDL-C及Cys C是T2DM合并OW/OB的独立影响因素。结论随着T2DM患者BMI增加,血清Cys C水平逐渐升高,提示Cys C可能参与T2DM患者BMI变化的发生发展。

Objective To investigate the correlation between the level of cystatin C（ Cys C）and different body mass index（ BMI） in patients with type 2 diabetes mellitus（ T2 DM）. Methods The clinical data of 160 patients with T2 DM was retrospectively analyzed. They were divided into normal weight（ NW） group（ n = 88）,over weight（ OW） group（ n = 42） and obesity（ OB） group（ n =30）. NW and OB were defined as BMI 〈 25 kg/m2 and BMI ≥ 28 kg/m2 according to the WHOWestern Pacific Region diagnostic set forth in 2000. The basic clinical data and biochemical indexes of all the subjects were collected. Spearman correlation analysis and Logistic regression analysis were used to evaluate the influencing factors for the different BMI in T2 DM. Results Compared with T2 DM-NW group,the level of serum Cys C was significantly increased in T2 DM-OW group and T2 DM-OB group,and Cys C in T2 DM-OB group was significantly higher than T2 DM-OW group（ P 〈0. 05 or P 〈 0. 01）. T2 DM-NW/OW/OB was positively correlated with BMI,hypertension,ALT,AST,TC,TG,LDL-C,Apo B and Cys C（ P 〈 0. 05 or P 〈 0. 01）. Logistic regression analysis showed that ALT,TG,LDL-C and Cys C were the independent risk factors for T2 DM with OW/OB（ P〈 0. 05 or P 〈 0. 01）. Conclusion With increasing of BMI in T2 DM,serum Cys C level gradually increase. It suggests that the increased Cys C maybe play an important role in the pathogenesis of the different BMI in T2 DM.