α-硫辛酸、莫沙比利联合甲钴胺治疗糖尿病神经源性膀胱效果分析

Effect of DL-Thioctic Acid Combined with Mecobalamin and Mosapride Combined with Mecobalamin in Treatment of Diabetic Neurogenic Bladder

目的:评价α-硫辛酸、莫沙必利联合甲钴胺治疗糖尿病神经源性膀胱效果。方法:选择2016年1月-2018年1月本院收治的60例糖尿病神经源性膀胱患者作为研究对象,按照随机数字表法分为对照组与分析组,每组30例。对照组给予莫沙必利联合甲钴胺治疗,分析组给予α-硫辛酸联合甲钴胺的联用方案治疗。比较两组临床疗效。结果:治疗后分析组尿流动力学指标改善效果和血清学指标改善效果均明显优于对照组,差异均有统计学意义(P<0.05)。结论:相较于莫沙必利联合甲钴胺治疗方案,α-硫辛酸与甲钴胺应用于糖尿病神经源性膀胱中可获得更理想临床疗效,有助于改善患者神经尿流动力学与血清指标水平,值得临床推广应用。

Objective：To evaluate the efficacy of DL-Thioctic Acid combined with Mecobalamin and Mosapride combined with Mecobalamin in the treatment of diabetic neurogenic bladder.Method：A total of 60 patients with diabetic neurogenic bladder treated in our hospital from January 2016 to January 2018 were divided into control group and analysis group according to table of random numbers,30 cases in each group.The control group was treated by Mosapride combined with Mecobalamin,and the analysis group was given DL-Thioctic Acid combined with Mecobalamin.The clinical efficacy were compared between the two groups.Result：After treatment,the improvement of urodynamic parameters and serum markers in the analysis group was significantly better than those in the control group,the differences were statistically significant（P〈0.05）.Conclusion：Compared to Mosapride combined with Mecobalamin,the treatment of DL-Thioctic Acid combined with Mecobalamin has better clinical effects in diabetic neurogenic bladders,and it can improve levels of urodynamic parameters and serum markers.It is worthy of clinical application.