非剥脱点阵激光、氨甲环酸单独应用和联合应用治疗黄褐斑的效果对比

Comparison Effect of Non-ablative Fractional Laser,Tranexamic Acid Alone or Combined Utilization in Treatment of Chloasma

目的:探讨非剥脱点阵激光、氨甲环酸单独应用和联合应用治疗黄褐斑的临床应用效果。方法:选取本院于2016年2月-2017年1月收治的87例黄褐斑患者作为研究对象,将采用非剥脱点阵激光治疗的29例患者作为对照1组,将采用氨甲环酸治疗的29例患者作为对照2组,将采用非剥脱点阵激光联合氨甲环酸治疗的29例患者作为研究组。比较三组临床疗效、干预前、干预后及随访6个月时临床症状评分变化情况。结果:研究组临床有效率(89.65%)显著高于对照1组(65.51%)与对照2组(62.06%),差异有统计学意义(P<0.05)。研究组干预后症状评分分别低于对照1组与对照2组,下降指数分别高于对照1组与对照2组,差异均有统计学意义(P<0.05)。研究组干预后随访6个月评分低于对照1组与对照2组,上升指数低于对照1组与对照2组,差异均有统计学意义(P<0.05)。结论:非剥脱点阵激光联合氨甲环酸治疗黄褐斑相较于非剥脱点阵激光、氨甲环酸单独应用而言,具有更好的临床疗效,病情控制更稳定,减少复发情况。

Objective：To investigate the clinical effect of non-ablative fractional laser,Tranexamic Acid alone or in combination in the treatment of chloasma.Method：A total of 87 cases of chloasma in our hospital from February 2016 to January 2017 were selected as the objects of study,29 patients were treated with nonablative fractional laser as control group 1,29 patients were treated with Tranexamic Acid as control group 2,and 29 patients treated with non-ablative fractional laser combined with Tranexamic Acid as research group.The clinical efficacy,clinical symptom scores before intervention,after intervention,and at 6 months of followup were compared between the three groups.Result：The clinical efficiency of the research group（89.65%） was significantly higher than those of the control group 1（65.51%）and the control group 2（62.06%）,the difference was statistically significant（P〈0.05）.The symptom score of the research group was lower than those of the control group 1 and the control 2 group,and the decline index was higher than that of the control group 1 and the control group 2,the differences were statistically significant（P〈0.05）.The symptom score for 6 months of the research group was lower than those of the control group 1 and the control group 2,the rising index for 6 months of the research group was lower than that of the control group 1 and the control group 2,the differences were statistically significant（P〈0.05）.Conclusion：The treatment of Non-ablative fractional laser combined with Tranexamic Acid in the chloasma has better clinical efficacy,more stable disease control and reduce recurrence.