基于PubMed的阿尔茨海默病治疗药物研究热点双聚类分析

Biclustering Analysis of Drug Therapy for Alzheimer's Disease Based on PubMed Database

目的:探索分析近五年对阿尔茨海默病(Alzheimer’s disease,AD)药物治疗的研究热点。方法:选用PubMed数据库,检索式为:"Alzheimer’s disease/drug therapy"[Majr]AND("2012/12/29"[PDat]:"2017/12/27"[PDat]),检索结果采用书目信息挖掘系统(BICOMS)软件进行常规文献计量学分析,使用g CLUTO 2.1软件进行聚类及可视化分析。结果:共检索到文献2 286篇,统计分析后划分为以下6个主题:AD的治疗药物可能通过抗氧化应激途径,改善AD的学习记忆功能障碍;合理构建和优化BACE1抑制剂可为AD药物治疗提供新的合成思路;不同治疗药物的效果依赖于AD的严重程度;新型合成的他克林类药物对AD具有良好的治疗作用;生物医学数据库有助于筛选新的AD治疗靶点;其他类型治疗药物对AD的影响。结论:双聚类研究热点分析方法很好地体现了目前临床对AD药物治疗的研究方向。

Objective：To explore and analysis the hotspots of drug therapy for Alzheimer＇s disease（AD） in recently five years.Method：The PubMed database was selected and the retrieval type was ＂Alzheimer＇s disease/drug therapy＂[Majr]AND（＂2012/12/29＂[PDat]：＂2017/12/27＂[PDat]）.The results were retrieved by bibliographic information mining system（BICOMS） software,and g CLUTO 2.1 software was used for biclustering analysis and visualization analysis.Result：A total of 2 286 literatures were retrieved.The statistical analysis was divided into six topics：Drug therapy for AD improved learning and memory dysfunction through anti-oxidative stress pathways.The rational construction and optimization of BACE1 inhibitors were provided new synthetic ideas for AD drug therapy.The effectiveness of different therapies depended on the severity of AD.Newly synthesized tacrine drugs had a good therapeutic effect on AD.Biomedical databases screened new therapeutic targets for AD.Effects of other types of drug therapy on AD.Conclusion：The biclustering analysis method is a good example of the current research direction on drug therapy for AD.