重组人粒细胞-巨噬细胞刺激因子在治疗糖尿病足创面中的疗效观察

Efficacy of Recombinant Human Granulocyte-macrophage Colony Stimulating Factor in Treatment of Diabetic Foot Wounds

目的:探讨重组人粒细胞-巨噬细胞集落刺激因子(rhGM-CSF)治疗糖尿病足创面的愈合率及临床疗效。方法:选取2016年1月-2017年4月本院糖尿病足住院患者100例,按照随机数字表法将其分为对照组和试验组,各50例。对照组给予常规换药治疗,观察组在对照组基础上均匀注射rhGM-CSF治疗。比较两组治疗第1、15、30、45、60天的创面愈合率及临床疗效。结果:对照组治疗第45天可达到有效(40%<愈合率≤80%),试验组治疗第30天可达到有效,治疗第45天可达到显效(创面愈合率>80%);治疗第15、30、45、60天,试验组创面愈合率均高于对照组,比较差异均有统计学意义(P<0.05)。结论:rhGM-CSF能有效的促进糖尿病足创面愈合。

Objective：To investigate the healing rate and clinical effect of recombinant human granulocytemacrophage colony stimulating factor（rhGM-CSF） in treatment of diabetic foot wounds.Method：A total of 100 patients with diabetic foot in our hospital from January 2016 to April 2017 were selected.According to the random number table method,they were divided into control group and experimental group,50 cases in each group.The control group was treated with conventional medicine,and experimental group was evenly injected with rhGMCSF on the basis ofcontrol group.The healing rate and clinical effect in 1 st,15 th,30 th,45 th and 60 th day, of treatment between two groups were compared.Result：The control group can achieve effective level（40%〈healing rate≤80%）in 45 th day of treatment,the experimental group can achieve effective level in 30 days of treatment,and can achieve significant effective level（healing rate〉80%） in 45 th day of treatment.Treatment of 1 th,15 th,30 th,45 th and 60 th day,the wound healing rate in experimental group were higher than those of control group,the differences were statistically significant（P〈0.05）.Conclusion：rhGM-CSF can effectively promote the wound healing of diabetic foot.