阿尔茨海默病与脑淀粉样血管病临床与影像学关联性研究

Clinical and Imaging Correlation of Alzheimer's Disease and Cerebral Amyloidosis

目的:分析阿尔茨海默病(AD)和脑淀粉样血管病(CAA)的临床关联性和影像学关联性。方法:选取2016年1月-2017年7月本院收治的15例AD患者(A组)、20例CAA患者(B组)、9例AD合并CAA患者(C组)。评价三组认知障碍进展程度,观察三组MRI影像学表现。结果:第1、2次评估时,A、B组患者MMSE评分、CDR评分、ADL评分、ADAS-Cog评分、MOCA评分比较,差异均无统计学意义(P>0.05);C组上述指标与A、B组比较,差异均有统计学意义(P<0.05)。MRI表现上,A组颞叶萎缩较明显,B组皮质萎缩较明显,C组全脑萎缩较明显。结论:AD、CAA的临床表现均以认知障碍为主,两者的合并发生会导致患者病情发展速度加快,两者互为疾病发展的促进因素。

Objective：To analyze the clinical relevance and imaging correlation of Alzheimer＇s disease（AD） and amyloid angiopathy（CAA）.Method：A total of 15 AD patients（A group）,20 CAA patients（B group） and 9 AD patients complicated with CAA（C group） were admitted to our hospital from January 2016 to July 2017 were selected.They were evaluated on the progress of cognitive impairment,and the MRI imaging findings of three groups were observed.Result：In the first,second assessment,the MMSE score,CDR score,ADL score,ADAS-Cog score and MOCA score of A and B group were compared,the differences were not statistically significant（P〉0.05）,the above indexes in C group were compared with those of A and B group,the differences were statistically significant（P〈0.05）.On the MRI performance,the atrophy of temporal lobe was more obvious in A group,the atrophy of cortex was more obvious in B group,and the whole brain atrophy was more obvious in C group.Conclusion：The clinical manifestations of AD and CAA have been mainly cognizant disorders,the combination of them can accelerate the development of patients＇ condition,and they are mutually promoting factors of disease development.