P-选择素水平对不稳定心绞痛患者MACE发生率的影响

Effect of P-selectin on major adverse cardiac events(MACE)in patients with unstable angina

目的:探讨血浆P-选择素水平对不稳定心绞痛(UAP)患者主要不良心血管事件(MACE)的影响。方法:选择2014年3月至2015年9月广西北海市卫生学校附属医院收治的156例UAP患者作为研究对象,根据基线血浆P-选择素水平将患者分为两组,其中A组76例(P-选择素>160.6μg/L),B组80例(P-选择素<160.6μg/L)。随访90d后,比较两组患者MACE发生率。结果:A组中,4例患者(5.3%)心脏性死亡,10例(13.2%)出现心肌梗死,40例(52.6%)出现恶性心律失常;B组1例(1.2%)心脏性死亡,4例(5.0%)出现心肌梗死,16例(20.0%)出现恶性心律失常。A组的MACE发生率(71.1%)明显高于B组(26.2%)(χ2=31.339,P<0.05)。结论:血浆高水平P-选择素的UAP患者更容易发生MACE。

Objective：To investigate the effect of plasma P-selectin level on the incidence of MACE in patients with unstable angina pectoris（UAP）.Methods：156 UAP patients in our hospital from March 2014 to September 2015 were selected and divided into two groups according to the plasma P-selectin level：76 cases in group A with P-selectin level〉160.6μg/L,and 80 cases in group B with P-selectin level〈160.6μg/L.All cases were followed up for 30 days,the incidence of MACE was compared between the two group.Results：The incidence of MACE in group A was 71.1%,which was significantly higher than that in group B（26.2%）（P〈0.05）.Conclusion：Patients with a high plasma level of P-selectin were more likely to suffer MACE.