肱动脉血流介导的血管舒张功能影响因素及其贡献度分析

Influencing factors of flow mediated dilation by brachial artery and the contribution analysis

目的:分析一般人群中肱动脉血流介导的血管舒张功能(FMD)的影响因素及其贡献度。方法:于2015年8—9月在广西融安县泗顶镇、融水县安陲乡两地招募研究对象795名,对其进行问卷调查、体格检查及血样采集。按性别分层,分别运用单因素、多因素线性回归及优势分析对男性、女性FMD的影响因素及贡献度进行分析。结果:男性FMD影响因素为肱动脉基础直径增加、中低体力活动、心率减慢、年龄增长、体重指数(Ibm)降低,其优势权重依次为69.50%、15.72%、6.61%、5.69%、2.48%;女性FMD影响因素为肱动脉基础直径增加、绝经状态、Ibm降低、高中及以上教育程度,其优势权重依次为66.75%、24.96%、6.61%、1.68%。结论:FMD的影响因素及其贡献度存在性别差异,提示应根据性别及影响因素贡献度制定更有针对性的心血管健康促进措施。

Objective：To analyze the factors influencing brachial artery flow-mediated dilatation（FMD）and the contribution of them in general population.Methods：From August to September 2015,795 subjects were recruited in Siding town,Rongan county and Anchui town,Rongshui county,Guangxi.Questionnaires,physical examinations and blood samples were collected.Univariate,multivariate linear regression and dominance analysis were used to analyze the factors influencing FMD and their contribution by sex.Results：Increased brachial artery diameter and age,decreased heart rate and body mass index（Ibm）,and low to moderate physical activity were factors for male FMD,and the dominant weight were 69.50%,15.72%,6.61%,5.69% and 2.48%,respectively.Increased basic diameter of brachial artery,menopause,decreased Ibm and high education level were factors for female FMD,and the dominant weight were 66.75%,24.96%,6.61% and 1.68%,respectively.Conclusion：There are differences in the factors influencing FMD and their contribution between male and female,suggesting that the individualized measures should be considered in promoting vascular health based on sex and the contribution of the influencing factors.