重症毛细支气管炎患儿淋巴细胞亚群变化的临床分析

Clinical analysis of lymphocyte subsets in children patients with severe bronchiolitis

目的探讨重症毛细支气管炎儿童淋巴细胞亚群的变化及临床意义。方法选取住院治疗的101例毛细支气管炎患儿,其中50例重症组、51例轻症组,以同期门诊体检的健康儿童49例为对照组。用流式细胞仪检测各组淋巴细胞亚群。结果重症组、轻症组CD3^+、CD3^+/CD8^+、CD16^+/CD56^+比值均低于正常对照组,以重症组最低(P<0.05);重症组、轻症组CD4^+/CD8^+、CD19^+比值均高于于正常对照组,以重症组最高(P<0.05)。重症组患儿中年龄<6个月组CD3^+、CD3^+/CD4^+、CD4^+/CD8^+比值均较高于6个月组(P<0.05)。结论淋巴细胞亚群失衡参与了重症毛细支气管炎的发生、发展,可使<6个月患儿更易发生重症毛细支气管炎。

Objective To investigate the changes and clinical significance of lymphocyte subsets in children with severe bronchiolitis. Methods The 101 children with bronchioliti admitted in author＇s hospital were divided into two groups：50 cases as severe group and 51 cases as slight group;49 healthy children were included as normal control group. Flow cytometry was applied to measure lymphocyte subsets. Results CD3^＋,CD3^＋/CD8^＋ and CD16^＋/CD56^＋ ratio of the children with severe and slight bronchiolitis was lower than control group,which was the lowest in control group（P〈0.05）. CD4^＋/CD8^＋,CD19^＋ ratio of the children with severe and slight bronchiolitis was higher than control group,which was the highest in control group（P〈0.05）. In the severe group,the ratio of CD3^＋、CD3^＋CD4^＋ and CD4^＋/CD8^＋ in the children aged 6 months was higher than that in the 6 months groups（P〈0.05）. Conclusion Lymphocyte subsets disorder is involved in the development and progression of severe bronchiolitis,which can cause severe bronchiolitis in children with 6 months.