肠道菌群与炎症性肠病关系的研究进展

Research progress on the relationship between intestinal flora and inflammatory bowel disease(IBD)

迄今为止,炎症性肠病(IBD)的准确病理机制尚不清楚,但研究者普遍认为与肠道共生菌群失调密切相关。故针对IBD发病时肠道菌群变化,阐述肠道菌群与IBD发病的相关性,肠道菌群在IBD发病机制、诊断及疾病分型的作用,以及展望随着人类对肠道黏膜免疫系统研究的不断完善,益生菌制剂将被广泛应用于IBD的治疗。

The exact pathological mechanism of inflammatory bowel disease（IBD） is unknown. The researchers generally thought that the pathological mechanism of IBD is closely related to the intestinal flora imbalance. In view of the change of intestinal flora,this article discusses the correlation between the pathogenesis of IBD and intestinal flora,as well the effect of intestinal flora on pathogenesis,diagnosis and disease subtypes of IBD. With the continuous improvement of the research on intestinal mucosa immune system,probiotics agents will be widely used in the treatment of IBD.