高脂饮食对犬生化指标及血液流变学的影响

Effect of high-fat diet on biochemical parameters and hemorheology in canine

本试验旨在研究高脂饮食对犬生化指标和血液流变学指标的影响。选取本地50只健康的45日龄杂交犬，随机分为两组，正常组15只，高脂组35只，分别饲喂基础饲料（正常组）、高脂饲料（高脂组）。试验为12周。每隔1周，采集1次血清，用于检测血清生化指标。于试验最后1d，每组随机选择15只犬，采集抗凝血，用于检测血液流变学指标。结果表明：与正常组检测结果相比，高脂组犬血清中TC、TG和LDL-C浓度均显著升高（P〈0．01或P〈0．05）。高脂组犬的全血黏度、红细胞压积、血浆黏度、全血高低切相对指标和全血高切还原黏度均显著升高（P〈0．01或P〈0．05）。由此可见，给予犬高脂饮食可出现高脂血症，并且血液流变学指标会发生明显的变化，对于犬高脂血的临床诊断，具有理论指导意义。

The present study was conducted to investigate the effects of high-fat diet on biochemical parameter and hemorheology. Fifty 45-day-old mongrels were divided into two groups,in control group 15 mongrels were fed with basic diet and in high-fat diet group 35 mongrels were fed with basic diet plus high fat,respectively. The trial lasted 12 weeks. The blood samples were collected for biochemical indexes once a week. The anticoagulant blood from 15 mongrels were collected for measuring hemo rheology. The results showed that serum TC, TG and LDL-C in high-fat diet group were significantly higher than in control group（P〈0.01 or P〈0.05）. Whole blood viscosity, plasma viscosity, hematocrit, whole blood high shear relative index, whole blood low shear rela- tive index,and whole blood high shear reduction viscosity were significantly higher than in control group（P〈0.01 or P〈0.05）. In conclusion,high-fat diet induced hyperlipidemia in canine and the change of hemorheology index,which provide a theoretical basis for clinical diagnosis of hyperlipi demia in canine.