收敛生肌散在肛裂术后创面治疗和防治感染中的作用分析

Effect of Shoulian Shengji Powder on Wound Healing After Anal Fissure and Proventing Infection

目的：分析收敛生肌散在肛裂术后创面治疗和防治感染中的作用。方法：选择本院2014年2月—2016年2月收治的肛裂患者62例进行回顾性分析,采用系统随机的方法分为对照组和观察组各31例,对照组采用凡士林油纱覆盖进行治疗,观察组采用紫草油纱加入外用生肌散进行治疗。观察两组患者治疗后的临床疗效、愈合情况、新肉芽组织中PDGF、VEGFFmRNA表达水平及术后感染的发生情况。结果：观察组患者总有效率为83.87%与对照组患者的64.52%相比效果明显更为优异,组间差异明显（P〈0.05）。术后第10天两组患者的创面平均愈合率比较无明显差异（P〉0.05）;观察组患者术后14 d、18 d创面愈合率分别是（59.7±9.8）%、（97.7±5.5）%明显高于对照组的（45.7±7.3）%、（81.5±7.4）%;且观察组患者创面愈合平均时间为（16.4±2）d明显少于对照组患者的（19.6±3.9）d。治疗后,对照组患者各项炎症因子指标水平明显高于观察组（P〈0.05）。治疗后,观察组患者新肉芽组织中PDGF、VEGFFmRNA表达水平分别为（2.97±0.48）ng/m L、（2.62±0.51）pg/m L明显高于对照组患者的（0.83±0.41）ng/m L、（0.62±0.72）pg/m L,组间比较存在明显差异（P〈0.05）。对照组患者术后创面感染率为25.81%明显高于观察组的患者3.22%,组间比较存在明显差异（P〈0.05）。结论：收敛生肌散可促进肛裂术后创面愈合,提高治疗疗效,增加新肉芽组织中PDGF、VEGFFmRNA表达水平,并减少患者术后感染的发生率。

Objective： To analyze of the role of Shoulian Shengji Powder in the treatment of wound healing after anal fissure and prevention and treatment of infection. Methods： Sixty-two cases with anal fissure failures were researched from May 2014 to May2016. According to random number table,they were divided into control group and treatment group,31 cases in each group. The control group was treated with vaseline oil yarn covering. The observation group was treated with Lithospermum oil yarn and Shoulian Shengji Powder for external use. We observed the clinical efficacy and healing of the two groups after treatment,the expression of PDGF,VEGF mRNA and the occurrence of postoperative infection in the new granulation tissue. Results： The total effective rate was 83. 87% in the observation group and 64. 52% in the control group and the difference was significant（ P〈0. 05）. The observation group＇s wound healing rates 14 d and 18 d respectively after operation were（ 59. 7 ± 9. 8） % and（ 97. 7± 5. 5） %,significantly higher than the control group＇s（ 45. 7 ± 7. 3） % and（ 81. 5 ± 7. 4） %. And the observation group＇s average wound healing time was（ 16. 4 ± 2） d,significantly less than the control group＇s（ 19. 6 ± 3. 9） d. The mean duration of wound healing in the observation group was（ 16. 4 ± 2） d,which was significantly lower than the control group＇ s（ 19. 6 ± 3. 9） d. After treatment,the levels of inflammatory factors were significantly higher in the control group than those in the observation group（ P〈0. 05）. After treatment,the expression levels of PDGF and VEGFF mRNA in the new granulation tissues were（ 2. 97 ± 0. 48）ng/m L and（ 2. 62 ± 0. 51） pg/m L,respectively,which were significantly higher than the control group＇s（ 0. 83 ± 0. 41） ng/m L and（ 0. 62 ± 0. 72） pg/m L and there was significant difference between the two groups（ P〈0. 05）. The rate of postoperative wound infection was 25. 81% in the control group,which was significantly higher than that in the observation group（ 3. 22%）. There was significant difference between the two groups（ P〈0. 05）. Conclusion： Shoulian Shengji Powder can promote the healing of anal fissure after wound healing,improve the therapeutic effect and increase the expressions of PDGF and VEGFF mRNA in new granulation tissue and it also can reduce the incidence of postoperative infection in patients.