中西医结合治疗中老年高血压的临床疗效及对血清hs-CRP、MMP9水平的影响

Effect of Integrated Traditional Chinese and Western Medicine on Middle-aged Hypertension and Its Effects on Serum hs-CRP and MMP9 Levels

目的：研究中西医结合治疗中老年高血压临床疗效及对血清超敏C反应蛋白（hypersensitive C-reactive protein,hs-CRP）、基质金属蛋白酶（matrix metalloprotein9,MMP9）水平的影响。方法：选取2015年10月—2017年1月期间在本院接受诊治的120例中老年高血压患者作为研究对象,根据随机数表法分为对照组、研究组,各60例。给予对照组患者苯磺酸氨氯地平片治疗,研究组患者在对照组治疗基础上实施中医辨证治疗,治疗2个月。观察并比较两组患者治疗前后血压水平、临床疗效及血清hs-CRP、MMP9水平变化。结果：治疗后,两组患者舒张压、收缩压均低于治疗前,且研究组低于对照组,差异有统计学意义（P〈0.05）;研究组治疗总有效率（96.7%）高于对照组（83.3%）,差异有统计学意义（P〈0.05）;两组患者治疗后血清hs-CRP、MMP9水平均低于治疗前,且研究组低于对照组,差异有统计学意义（P〈0.05）。结论：中西医结合治疗中老年高血压疗效显著,能有效改善患者舒张压、收缩压水平,调节血清hs-CRP、MMP9水平,促进心肌收缩、舒张功能恢复,值得临床推荐。

Objective： To study the effect of combined Chinese medicine and western on the efficacy of hypersensitive C-reactive protein（ hs-CRP） and matrix metalloproteinase 9（ MMP9） in middle-aged and elderly patients with hypertension. Methods：A total of 120 elderly patients with hypertension were enrolled in our hospital from October 2015 to January 2017 were selected as the object of the study. According to the random number table method,the patients were divided into control group and research group,each group 60 cases. The control group received nifedipine controlled-release tablets,captopril treatment,and patients in the study group were given the traditional Chinese medicine treatment on the basis of conventional treatment. The levels of blood pressure,clinical efficacy and serum hs-CRP and MMP9 were observed and compared between the two groups before and after treatment. Results： After treatment,the diastolic blood pressure and systolic blood pressure of the two groups were lower than those before treatment,and the study group＇ s was lower than the control group＇ s,and the difference was statistically significant（ P〈0. 05）. The total effective rate（ 96. 7%） in the study group was higher than that in the control group（ 83. 3%）,and the difference was statistically significant（ P〈0. 05）. The levels of serum hs-CRP and MMP9 in the two groups were lower than those before treatment,and the difference was statistically significant（ P〈0. 05）. Conclusion： Combined with traditional Chinese and Western medicine treatment of middle-aged hypertension can effectively improve the patients＇ diastolic blood pressure and systolic blood pressure levels,regulate serum hs-CRP,MMP9 levels,promote myocardial contraction and diastolic function recovery,worthy of clinical recommendations.