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Parameter identification through mode isolation for reaction-diffusion systems on arbitrary geometries

Parameter identification through mode isolation for reaction-diffusion systems on arbitrary geometries
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摘要 We present a computational framework for isolating spatial patterns arising in the steady states of reaction-diffusion systems. Such systems have been used to model many nat- ural phenomena in areas such as developmental and cancer biology, cell motility and material science. In many of these applications, often one is interested in identifying parameters which will lead to a particular pattern for a given reaction-diffusion model. To attempt to answer this, we compute eigenpairs of the Laplacian on a variety of domains and use linear stability analysis to determine parameter values for the system that will lead to spatially inhomogeneous steady states whose patterns correspond to particular eigenfunctions. This method has previously been used on domains and surfaces where the eigenvalues and eigenfunctions are found analytically in closed form. Our contribution to this methodology is that we numerically compute eigenpairs on arbitrary domains and surfaces. Here we present examples and demonstrate that mode isolation is straightforward especially for low eigenvalues. Additionally, we show that in some cases the inhomogeneous steady state can be a linear combination of eigenfunctions. Finally,we show an example suggesting that pattern formation is robust on similar surfaces in cases that the surface either has or does not have a boundary.
出处 《International Journal of Biomathematics》 SCIE 2018年第4期149-178,共30页 生物数学学报(英文版)
关键词 Reaction diffusion systems finite elements parameter identification eigen-value problem. 系统 参数鉴定 反应 线性稳定性分析 几何学 计算框架 拉普拉斯算符 空间模式
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