运动与DNA甲基化的研究进展

Research progress on exercise and DNA methylation

DNA甲基化是基因表观遗传的关键修饰,调控基因表达,在肥胖和II型糖尿病发生机制中起关键作用。针对DNA甲基化检测最经济高效的技术是RRBS技术。研究表明急性和慢性运动与DNA甲基化模式和基因表达的变化有关。介绍了DNA甲基化及其RRBS技术,总结目前关于运动与DNA甲基化的相关研究,以期深入了解运动诱导DNA甲基化的分子机制,并为未来研究提供方向。

DNA methylation is a key modification of gene epigenetics and regulates gene expression. It plays a key role in the pathogenesis of obesity and type 2 diabetes. The most cost-effective technique for detecting DNA methylation is RRBS technology. Studies have shown that acute and chronic exercise is associated with changes in DNA methylation patterns and gene expression. This article briefly introduced DNA methylation and its RRBS technology,summed up the current research on exercise and DNA methylation,in order to understand the molecular mechanisms of exercise-induced DNA methylation,and provide direction for future research.