人类免疫缺陷病毒感染孕妇生殖道感染与妊娠结局的相关性研究

Study on the relationship between reproductive tract infection and pregnancy outcome in pregnant women with HIV infection

目的探讨人类免疫缺陷病毒(human immunodeficiency virus,HIV)感染孕妇生殖道感染与妊娠结局的相关性。方法选取2015年6月至2017年6月广州市第八人民医院收治的HIV感染孕妇162例为研究对象。将生殖道感染检测阳性者分为感染组,将无任何感染的分为非感染组;将感染组中不接受治疗者分为感染非治疗组,接受治疗者分为感染治疗组。观察各项感染率以及各组妊娠结局。结果 162例妊娠合并HIV感染患者中,138例存在生殖道感染(85.19%),生殖道感染孕妇合并HIV感染者最多为外阴阴道假丝酵母菌病(64例),其次为细菌性阴道病(28例)。不良妊娠结局感染组(52例)多于非感染组(2例)(P<0.05);感染非治疗组不良妊娠结局(38例)多于感染治疗组(14例)(P<0.05)。新生儿HIV感染率感染组和非感染组比较差异无统计学意义(P>0.05)。结论妊娠合并HIV感染患者十分容易发生生殖道感染,可增加不良妊娠结局的发生率,积极抗感染治疗有助于改善妊娠结局。

Objective To investigate the correlation between reproductive tract infection and pregnancy outcome in pregnant women with human immunodeficiency virus （HIV） infection. Methods 162 cases of HIV - infected pregnant women admitted in Guangzhou No. 8 People＇s Hospital from June 2015 to June 2017 were selected. Patients with positive reproductive tract infections were set as infection groups, and those without any infection were set as non - infection groups. Those who did not receive treatment in the infection group were divided into untreatment group, and those who received treatment were divided into treatment group. The infection rate and the outcome of each group were observed. Results Among the 162 patients with HIV infection, 138 cases had genital tract infection, accounting for 85. 19 %. The majority of women with genital tract infection with HIV infection were with vulvovaginal candidiasis（64 cases）, followed by bacterial vaginosis（28 cases）. There were 52 cases of adverse pregnancy outcome in the infectedgroup and 2 cases in the non - infected group （ P 〈 0. 05 ）. The adverse pregnancy outcome in the untreatment group （ 38 cases） was significantly higher than that in the treatment group（ 14 cases） （P 〈 0. 05 ）. There were 38 cases of adverse pregnancy outcome in the untreatment group and 14 cases in the treatment group. The incidence of adverse pregnancy outcome in the untreatment group was significantly higher than that in the infection group （ P 〈 0. 05 ）. Neonatal HIV infection rates were not statistically different （ P 〉 0. 05 ）. Conclusion Pregnancy with HIV infection is very prone to genital tract infection, can increase the incidence of adverse pregnancy outcomes. Active anti - infective treatment can help improve the outcome of pregnancy.